2024
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response
Jaschke N, Breining D, Hofmann M, Pählig S, Baschant U, Oertel R, Traikov S, Grinenko T, Saettini F, Biondi A, Stylianou M, Bringmann H, Zhang C, Yoshida T, Weidner H, Poller W, Swirski F, Göbel A, Hofbauer L, Rauner M, Scheiermann C, Wang A, Rachner T. Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response. Immunity 2024, 57: 364-378.e9. PMID: 38301651, PMCID: PMC10923082, DOI: 10.1016/j.immuni.2024.01.005.Peer-Reviewed Original ResearchMeSH KeywordsBone MarrowHistone AcetyltransferasesHistonesHumansHypothalamo-Hypophyseal SystemNeutrophilsConceptsCorticotropin-releasing hormone receptor 1Hypothalamus-pituitary-adrenal glandAdrenocorticotropic hormoneBone marrowGranulocyte colony-stimulating factorAugmented host defenseMobilization of leukocytesColony-stimulating factorHistone acetyltransferase inhibitionHormone receptor 1Leukemic transformationG-CSFNeutrophil mobilizationReceptor 1Leukocyte mobilizationLeukocyte distributionHistone acetyltransferaseLeukocyte compartmentNeuroendocrine loopHost defenseEndocrine stress responseLeukocytesMarrowBloodReversible inhibition
2011
Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury
Li L, Black R, Ma Z, Yang Q, Wang A, Lin F. Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. American Journal Of Physiology. Renal Physiology 2011, 302: f9-f19. PMID: 21937606, PMCID: PMC3251347, DOI: 10.1152/ajprenal.00377.2011.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryMouse hematopoietic stemProgenitor cellsHematopoietic stemEpithelial marker E-cadherinRenal ischemic injuryTubular cell deathCell fate conversionMarker E-cadherinEmbryonic kidney organ cultureHistone deacetylase inhibitorsKidney organ culturesIschemic injuryKidney functionPostischemic kidneyTubular repairRenal capsuleRenal repairRenotrophic factorIGF-1Intravenous injectionEffective treatmentFate conversionEpithelial proliferation