2024
A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections
Flatby H, Ravi A, Liyanarachi K, Afset J, Rasheed H, Brumpton B, Hveem K, Åsvold B, DeWan A, Solligård E, Damås J, Rogne T. A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections. The Journal Of Infectious Diseases 2024, jiae231. PMID: 38713594, DOI: 10.1093/infdis/jiae231.Peer-Reviewed Original ResearchGenome-wide association studiesMichigan Genomics InitiativeAssociation studiesUpper UTIMendelian randomizationMR analysisUpper urinary tract infectionRisk factorsPotential causal risk factorsCardiometabolic risk factorsModifiable risk factorsSex-stratified analysesCausal risk factorUrinary tract infectionGenome-wideFemale-only analysisGenetic lociPotential causal relationshipGenome InitiativeHealth StudyUK BiobankHLA-DQA2LociTract infectionsSmoking score
2023
Systematic review and meta-analysis of the genetics of peripheral arterial disease
Ochoa Chaar C, Kim T, Alameddine D, DeWan A, Guzman R, Dardik A, Grossetta Nardini H, Wallach J, Kullo I, Murray M. Systematic review and meta-analysis of the genetics of peripheral arterial disease. JVS Vascular Science 2023, 5: 100133. PMID: 38314202, PMCID: PMC10832467, DOI: 10.1016/j.jvssci.2023.100133.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenome-wide association studiesDNA variantsWide association studyRecent genome-wide association studiesSmall candidate gene studiesCandidate gene studiesGWAS studiesCandidate genesAssociation studiesGene studiesGenetic researchGeneticsOnly variantVariantsHepatic lipaseGenesProgressionSignificant variationSaddlepoint approximations to score test statistics in logistic regression for analyzing genome‐wide association studies
Johnsen P, Bakke Ø, Bjørnland T, DeWan A, Langaas M. Saddlepoint approximations to score test statistics in logistic regression for analyzing genome‐wide association studies. Statistics In Medicine 2023, 42: 2746-2759. PMID: 37094813, DOI: 10.1002/sim.9746.Peer-Reviewed Original ResearchConceptsSaddlepoint approximationGenome-wide association studiesSaddlepoint approximation methodTest statisticScore test statistic
2020
Genetic Determinants of Blood Cell Traits Play a Role in Susceptibility to Acute Lymphoblastic Leukemia
Kachuri L, Jeon S, DeWan A, Metayer C, Witte J, Ma X, Chiang C, Wiemels J, de Smith A. Genetic Determinants of Blood Cell Traits Play a Role in Susceptibility to Acute Lymphoblastic Leukemia. Blood 2020, 136: 10-11. DOI: 10.1182/blood-2020-141443.Peer-Reviewed Original ResearchGenome-wide association studiesBlood cell traitsLD score regressionTrait variationTwo-stage genome-wide association studyGenome-wide single nucleotide polymorphism (SNP) dataGenome-wide SNP dataTrait-specific lociScore regressionSingle nucleotide polymorphism dataNucleotide polymorphism dataLikely causal variantsEuropean ancestryCell type ratiosEuropean ancestry individualsMulti-trait analysisUK BiobankGenetic variationPolymorphism dataGenetic basisSNP dataCausal variantsPutative novelRisk lociGenetic level
2018
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21
Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nature Communications 2018, 9: 286. PMID: 29348612, PMCID: PMC5773513, DOI: 10.1038/s41467-017-02596-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCaliforniaChild, PreschoolChromosomes, Human, Pair 17Chromosomes, Human, Pair 8FemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHispanic or LatinoHumansInfantInfant, NewbornMalePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsConceptsNew risk lociRisk lociGenome-wide association studiesGrowth regulation pathwaysGenetic associationAcute lymphoblastic leukemiaNovel genetic associationsChildhood acute lymphoblastic leukemiaGenetic Epidemiology ResearchTranscription factorsStrong genetic associationGene expressionAssociation studiesLymphocyte developmentMYC oncogeneChromosome 17q12Oncology GroupLymphoblastic leukemiaLociChildren's Oncology GroupCalifornia Childhood Leukemia StudyChildhood Leukemia StudyStructural contactsYear of birthNon-Latino whites
2009
Detecting essential and removable interactions in genome-wide association studies.
Dewan A, Dubrow R, Hoh J, Liu X, Wu C, Yang Y, Ying Z, Zhang H. Detecting essential and removable interactions in genome-wide association studies. Statistics And Its Interface 2009, 2: 161-170. PMID: 21165165, PMCID: PMC3002050, DOI: 10.4310/sii.2009.v2.n2.a6.Peer-Reviewed Original Research