2015
Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor–Binding Protein-3 in Critical Illness*
Ahasic AM, Tejera P, Wei Y, Su L, Mantzoros CS, Bajwa EK, Thompson BT, Christiani DC. Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor–Binding Protein-3 in Critical Illness*. Critical Care Medicine 2015, 43: 2651-2659. PMID: 26427594, PMCID: PMC4651824, DOI: 10.1097/ccm.0000000000001314.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAcute DiseaseAge FactorsAgedAged, 80 and overAPACHEBody Mass IndexChronic DiseaseCritical IllnessFemaleGenotypeHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IIntensive Care UnitsLinear ModelsMaleMiddle AgedPhenotypePolymorphism, GeneticProspective StudiesRisk FactorsSex FactorsConceptsInsulin-like growth factor-binding protein-3Insulin-like growth factor-1Acute respiratory distress syndromeGrowth factor-1Respiratory distress syndromeInsulin-like growth factor-binding protein-3 levelsProtein-3 levelsCritical illnessBody mass indexDistress syndromeProtein 3Acute PhysiologyMass indexFactor 1Chronic Health Evaluation III scoreInsulin-like growth factor-1 levelsChronic Health Evaluation IIISepsis/septic shockGrowth factor-1 levelsTotal insulin-like growth factor-1Insulin-like growth factorAcute critical illnessAcute hepatic dysfunctionReceipt of corticosteroidsLarge prospective studiesPersonalized Critical Care Medicine: How Far Away Are We?
Ahasic AM, Christiani DC. Personalized Critical Care Medicine: How Far Away Are We? Seminars In Respiratory And Critical Care Medicine 2015, 36: 809-822. PMID: 26595041, DOI: 10.1055/s-0035-1564852.Peer-Reviewed Original ResearchConceptsCritical illnessClinical trialsAcute respiratory distress syndromeRespiratory distress syndromeIntensive care unitCritical care arenaDirect patient careUnique risk factorsMulti-biomarker panelAccurate diagnostic classificationMajor clinical applicationsPrecise medical careDistress syndromeCare unitPoor outcomeRisk factorsTreatment decisionsIndividual patientsClinical careClinical utilitySuch biomarkersMedical carePatient careClinical useIllness
2012
Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
Tejera P, Meyer NJ, Chen F, Feng R, Zhao Y, O'Mahony DS, Li L, Sheu CC, Zhai R, Wang Z, Su L, Bajwa E, Ahasic AM, Clardy PF, Gong MN, Frank AJ, Lanken PN, Thompson BT, Christie JD, Wurfel MM, O'Keefe GE, Christiani DC. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. Journal Of Medical Genetics 2012, 49: 671. PMID: 23048207, PMCID: PMC3654537, DOI: 10.1136/jmedgenet-2012-100972.Peer-Reviewed Original ResearchConceptsAcute lung injuryALI/ARDSIndirect lung injuryRisk of ARDSRespiratory distress syndromeLung injuryExtrapulmonary causesDistress syndromeIndirect insultsSingle nucleotide polymorphismsStage IIAcute respiratory distress syndromeDevelopment of ARDSGenetic variantsGenetic risk factorsIll Caucasian patientsFunctional single nucleotide polymorphismsALI/Extrapulmonary injuryPulmonary sepsisPulmonary injuryExtrapulmonary originCaucasian patientsRisk factorsARDS
2011
IGF1 and IGFBP3 in acute respiratory distress syndrome
Ahasic AM, Zhai R, Su L, Zhao Y, Aronis KN, Thompson BT, Mantzoros CS, Christiani DC. IGF1 and IGFBP3 in acute respiratory distress syndrome. European Journal Of Endocrinology 2011, 166: 121-129. PMID: 22004906, PMCID: PMC3757506, DOI: 10.1530/eje-11-0778.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeLevels of IGF1Development of ARDSRespiratory distress syndromeIGFBP3 levelsARDS casesDistress syndromePersistent acute respiratory distress syndromeFibrotic lung diseaseSeverity of illnessIntensive care unitCase-cohort studyRelevant clinical covariatesCause mortalityConsecutive patientsCare unitLung diseaseRisk factorsClinical covariatesPlasma IGF1Parent studyCase statusPatientsIGF pathwayDay 60