2024
Clonal cytopenia of undetermined significance: definitions, risk and therapeutic targets
Taborda C, Zeidan A, Mendez L. Clonal cytopenia of undetermined significance: definitions, risk and therapeutic targets. Frontiers In Hematology 2024, 3: 1419323. DOI: 10.3389/frhem.2024.1419323.Peer-Reviewed Original ResearchClonal hematopoiesis of indeterminate potentialClonal hematopoiesisClonal cytopeniaSomatic genetic alterationsTherapeutic targetStem/progenitor cell populationsRisk stratification toolBlood of individualsMyeloid malignanciesMyeloid neoplasmsHematologic malignanciesPotential therapeutic targetIndeterminate potentialRisk stratificationBlood countGenetic alterationsStratification toolClinical investigationNatural historyCell populationsCytopeniasMalignancyBloodRiskCytopenia(s
2023
Targeting apoptosis dysregulation in myeloid malignancies - The promise of a therapeutic revolution
Santinelli E, Pascale M, Xie Z, Badar T, Stahl M, Bewersdorf J, Gurnari C, Zeidan A. Targeting apoptosis dysregulation in myeloid malignancies - The promise of a therapeutic revolution. Blood Reviews 2023, 62: 101130. PMID: 37679263, DOI: 10.1016/j.blre.2023.101130.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute myeloid leukemiaMyeloid malignanciesLeukemia cell survivalBcl-2 signalingPro-apoptotic agentsClinical studiesMyeloid leukemiaMyeloid neoplasmsTherapeutic revolutionMolecular alterationsMyeloid neoplasiaTherapeutic landscapeSpecific drugsApoptosis dysregulationSynergistic efficacyNew drugsMechanism of apoptosisDrugsMalignancyCombination strategiesCell survivalAttractive targetApoptotic pathwayTreatmentApoptosisSpectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms
Xie Z, Chen E, Mendez L, Komrokji R, Zeidan A. Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms. The Cancer Journal 2023, 29: 130-137. PMID: 37195768, DOI: 10.1097/ppo.0000000000000656.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClonal hematopoiesisHigh-risk patientsRisk of progressionSuch patientsUndetermined significanceAge-related diseasesHematologic malignanciesClonal cytopeniaMyeloid neoplasmsHigh riskUnmet needMyeloid malignanciesNatural historyCH managementPatientsMalignancySignificant knowledge gapsRiskHematopoiesisCytopeniasNeoplasmsSyndrome
2022
Umbrella Trial in Myeloid Malignancies: The Myelomatch National Clinical Trials Network Precision Medicine Initiative
Little R, Othus M, Assouline S, Ansher S, Atallah E, Lindsley R, Freidlin B, Gore S, Harris L, Hourigan C, Ivy S, Jiwani S, Langan E, Luger S, Michaelis L, Odenike O, Patton D, Perales M, Radich J, Ramineni B, Salk J, Stiff P, Stock W, Stone R, Uy G, Williams P, Wood B, Worthington K, Yee L, Zeidan A, Zhang J, Litzow M, Erba H. Umbrella Trial in Myeloid Malignancies: The Myelomatch National Clinical Trials Network Precision Medicine Initiative. Blood 2022, 140: 9057-9060. DOI: 10.1182/blood-2022-169307.Peer-Reviewed Original ResearchTreatment of myelodysplastic syndromes in the era of precision medicine and immunomodulatory drugs: a focus on higher-risk disease
Mohty R, Al Hamed R, Bazarbachi A, Brissot E, Nagler A, Zeidan A, Mohty M. Treatment of myelodysplastic syndromes in the era of precision medicine and immunomodulatory drugs: a focus on higher-risk disease. Journal Of Hematology & Oncology 2022, 15: 124. PMID: 36045390, PMCID: PMC9429775, DOI: 10.1186/s13045-022-01346-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh-risk diseaseMyelodysplastic syndromeAcute myeloid leukemiaHeterogeneous clonal diseaseHematopoietic cell transplantationRisk of progressionDifferent hematologic malignanciesImmune therapyImmunomodulatory drugsCell transplantationHematologic malignanciesMyeloid leukemiaNovel therapiesMyeloid neoplasmsTherapeutic approachesClonal diseaseDisease pathophysiologyDiseasePrecision medicineSyndromeTherapyVariable degreesCytopeniasTransplantationMalignancy
2017
The skin as a window to the blood: Cutaneous manifestations of myeloid malignancies
Li AW, Yin ES, Stahl M, Kim TK, Panse G, Zeidan AM, Leventhal JS. The skin as a window to the blood: Cutaneous manifestations of myeloid malignancies. Blood Reviews 2017, 31: 370-388. PMID: 28732587, DOI: 10.1016/j.blre.2017.07.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCutaneous manifestationsMyeloid malignanciesMyeloid diseasesCommon cutaneous manifestationStage of diseaseHematologists/oncologistsSignificant clinical implicationsMalignant hematopoietic cellsCutaneous involvementSkin manifestationsTargeted agentsSkin findingsClinical reviewCutaneous reactionsDermatologic findingsPrognostic valueImmune statusDiagnostic challengeEarly recognitionHematologic malignanciesMalignancyClinical implicationsDiseaseManifestationsHematopoietic cells
2015
Myelodysplastic syndromes: from conductiong clinical trials of novel therapies to evaluating real-life effectiveness of exisiting therapies
Zeidan A. Myelodysplastic syndromes: from conductiong clinical trials of novel therapies to evaluating real-life effectiveness of exisiting therapies. International Journal Of Hematologic Oncology 2015, 4: 215-217. DOI: 10.2217/ijh.15.25.Peer-Reviewed Original ResearchMyelodysplastic syndromeHematologic malignanciesNovel therapiesYale Cancer CenterReal-life effectivenessMyeloid hematologic malignanciesHematology/oncology fellowshipRochester General HospitalInternal medicine residencyCancer CenterClinical trialsGeneral HospitalClinical investigationFaculty of MedicineOncology fellowshipsMalignancyTherapyClinical interestTranslational researchMedicine residencyOutcomes researchMBBS degreeMedicineJohns Hopkins UniversityResearch Fellowship
2014
Stem cells in gastrointestinal cancers: The road less travelled.
Mikhail S, Zeidan A. Stem cells in gastrointestinal cancers: The road less travelled. World Journal Of Stem Cells 2014, 6: 606-13. PMID: 25426257, PMCID: PMC4178260, DOI: 10.4252/wjsc.v6.i5.606.Peer-Reviewed Original ResearchCancer stem cellsGastrointestinal malignanciesNew therapeutic optionsFormation of CSCsGeneration of CSCsRole of dysregulationWnt/β-cateninStem cellsGastrointestinal neoplasmsTherapeutic optionsGastroesophageal tumorsGastrointestinal cancerTherapeutic strategiesTumor growthMalignant cellsMolecular abnormalitiesSignificant optimismCancerCancer resistanceΒ-cateninPatientsMalignancyTransformation growthPrecise targetingPotential utility