2023
Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals
Dettmer A, Chusyd D. Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals. Neuroscience & Biobehavioral Reviews 2023, 152: 105297. PMID: 37391110, PMCID: PMC10529948, DOI: 10.1016/j.neubiorev.2023.105297.Peer-Reviewed Original Research
2022
Early life adversity and males: Biology, behavior, and implications for fathers’ parenting
Condon EM, Dettmer A, Baker E, McFaul C, Stover CS. Early life adversity and males: Biology, behavior, and implications for fathers’ parenting. Neuroscience & Biobehavioral Reviews 2022, 135: 104531. PMID: 35063493, PMCID: PMC9236197, DOI: 10.1016/j.neubiorev.2022.104531.Peer-Reviewed Original ResearchConceptsEarly life adversityFathers' parentingLife adversityNon-human animal literatureEffects of ELANeurocognitive functioningChild developmentAnimal literatureLittle empirical researchParentingUnique influenceIntergenerational transmissionIntervention developmentBehavioral pathwaysFuture researchAdversityEmpirical researchConceptual modelGene-environment interactionsFathersEmpirical studyHormone receptorsNeurobiologyFunctioningMales
2016
Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation
Massart R, Nemoda Z, Suderman MJ, Sutti S, Ruggiero AM, Dettmer AM, Suomi SJ, Szyf M. Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation. Development And Psychopathology 2016, 28: 1259-1272. PMID: 27687908, PMCID: PMC6590057, DOI: 10.1017/s0954579416000833.Peer-Reviewed Original ResearchConceptsDNA methylation profilesDNA methylation changesMethylation profilesMethylation changesGenome-wide DNA methylation changesEpigenetic programsDevelopmental evolutionEpigenetic processesDNA methylationAdult phenotypeDevelopmental dynamicsNormal evolutionGenesMethylationEvolutionPhenotypeEarly life eventsEarly life experiencesEffects of sexFemalesEarly life adversityT lymphocytesNonhuman primatesRodentsPrimatesAssociations between early life experience, chronic HPA axis activity, and adult social rank in rhesus monkeys
Dettmer AM, Wooddell LJ, Rosenberg KL, Kaburu SS, Novak MA, Meyer JS, Suomi SJ. Associations between early life experience, chronic HPA axis activity, and adult social rank in rhesus monkeys. Social Neuroscience 2016, 12: 92-101. PMID: 27063359, PMCID: PMC6528805, DOI: 10.1080/17470919.2016.1176952.Peer-Reviewed Original ResearchConceptsChronic HPA axis activityHair cortisol concentrationsHPA axis activityHealth outcomesEarly life experiencesAxis activityAxis regulationRhesus monkeysNeuroendocrine stress regulationSocioeconomic statusHPA axis regulationAdrenal axis regulationAdverse health outcomesFemale rhesus monkeysEarly life adversityRisk factorsAdult social statusNR monkeysCortisol concentrationsLife adversityMonkeysOutcomesEarly experienceMonthsLife experiences
2011
Physiological and behavioral adaptation to relocation stress in differentially reared rhesus monkeys: Hair cortisol as a biomarker for anxiety-related responses
Dettmer AM, Novak MA, Suomi SJ, Meyer JS. Physiological and behavioral adaptation to relocation stress in differentially reared rhesus monkeys: Hair cortisol as a biomarker for anxiety-related responses. Psychoneuroendocrinology 2011, 37: 191-199. PMID: 21715101, PMCID: PMC3196800, DOI: 10.1016/j.psyneuen.2011.06.003.Peer-Reviewed Original ResearchConceptsMonths of ageHair cortisolCortisol levelsAnxiety scoresMonth 6Anxious behaviorInfant monkeysMonths of lifeYears of ageElevated hair cortisolEarly life adversityElevated cortisol levelsAnxiety-related responsesRhesus monkey infantsHigher cortisol levelsHair cortisol concentrationsRapid physiological adaptationsMPR groupStress-related health problemsMonth 8PR groupSPR groupMajor life stressorsDay 14Cortisol concentrations