2021
Sex-dependent role for EPHB2 in brain development and autism-associated behavior
Assali A, Cho JY, Tsvetkov E, Gupta AR, Cowan CW. Sex-dependent role for EPHB2 in brain development and autism-associated behavior. Neuropsychopharmacology 2021, 46: 2021-2029. PMID: 33649502, PMCID: PMC8429442, DOI: 10.1038/s41386-021-00986-8.Peer-Reviewed Original ResearchConceptsLayer V pyramidal neuronsAutism spectrum disorderSex-dependent roleAutism-associated behaviorsAttention deficit hyperactivity disorderPathophysiology of ASDSex-specific effectsNovo nonsense mutationFemale patientsPyramidal neuronsMotor hyperactivityIntrinsic excitabilityCortical functionRepetitive behaviorsSynaptic plasticityRelated disordersMemory deficitsBrain developmentHypofunctionReceptor tyrosine kinasesMiceHyperactivity disorderIntellectual disabilityDisordersEphB2
2018
PAC1R Genotype to Phenotype Correlations in Autism Spectrum Disorder
Goodrich M, Armour AC, Panchapakesan K, You X, Devaney J, Knoblach S, Sullivan CAW, Herrero MJ, Gupta AR, Vaidya CJ, Kenworthy L, Corbin JG. PAC1R Genotype to Phenotype Correlations in Autism Spectrum Disorder. Autism Research 2018, 12: 200-211. PMID: 30556326, PMCID: PMC6665682, DOI: 10.1002/aur.2051.Peer-Reviewed Original ResearchConceptsResting-state functional connectivity differencesAutism spectrum disorderHuman amygdalaRight middle temporal gyrusFunctional connectivity differencesHigher functional connectivityEarly postnatal stagesNumerous neurodevelopmental disordersMiddle temporal gyrusGC genotypeBrain trajectoriesRisk genotypesSocial deficitsConnectivity differencesAmygdalaTemporal gyrusFunctional connectivityBrain connectivityPostnatal stagesTime pointsNeurodevelopmental disordersMiceCritical time pointsMultimodal approachPossible alterations