More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome
Minteer C, Thrush K, Gonzalez J, Niimi P, Rozenblit M, Rozowsky J, Liu J, Frank M, McCabe T, Sehgal R, Higgins-Chen A, Hofstatter E, Pusztai L, Beckman K, Gerstein M, Levine M. More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome. Science Advances 2023, 9: eadf4163. PMID: 37467337, PMCID: PMC10355820, DOI: 10.1126/sciadv.adf4163.Peer-Reviewed Original ResearchConceptsStem cell divisionImmortalized human cellsTissue-specific cancer riskTumorigenic stateCell divisionDNA methylationEpigenetic changesAge-related accumulationHuman cellsMultiple tissuesSomatic mutationsClinical tissuesTissue differencesEpigenomeCellsTissueNormal tissuesMethylationMutationsReplicationNormal breast tissueSignaturesVitroAccumulationDivisionFrailty Resilience Score: A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival
Milman S, Lerman B, Ayers E, Zhang Z, Sathyan S, Levine M, Ye K, Gao T, Higgins-Chen A, Barzilai N, Verghese J. Frailty Resilience Score: A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival. The Journals Of Gerontology Series A 2023, 78: 1771-1777. PMID: 37246648, PMCID: PMC10562888, DOI: 10.1093/gerona/glad138.Peer-Reviewed Original ResearchConceptsMultivariable-adjusted analysesHazard of mortalityPhenotypic frailtyBaseline frailtyOverall survivalEffective therapyHigh riskFrailtyResilience AssociatedOlder adultsGenetic riskIdentification of factorsReliable predictorMortalityResilience scoresSurvivalProteomic profilesRiskReliable measureDeviation increaseTherapyCohort