2024
Predicting criminal offence in adolescents who exhibit antisocial behaviour: a machine learning study using data from a large randomised controlled trial of multisystemic therapy
Suh J, Saunders R, Simes E, Delamain H, Butler S, Cottrell D, Kraam A, Scott S, Goodyer I, Wason J, Pilling S, Fonagy P. Predicting criminal offence in adolescents who exhibit antisocial behaviour: a machine learning study using data from a large randomised controlled trial of multisystemic therapy. European Child & Adolescent Psychiatry 2024, 1-10. PMID: 39377792, DOI: 10.1007/s00787-024-02592-7.Peer-Reviewed Original ResearchMaternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression.
Lindley Baron-Cohen K, Fearon P, Meins E, Feldman R, Hardiman P, Rosan C, Fonagy P. Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression. Development And Psychopathology 2024, 1-12. PMID: 39363731, DOI: 10.1017/s0954579424001585.Peer-Reviewed Original ResearchMaternal mind-mindednessMind-mindednessMind-related commentsStudy 1Study 2Mothers' appropriate mind-related commentsLevels of mind-mindednessMothers' caregiving representationsPostnatal depressionSymptoms of depressionParent-child interactionsChildren's social developmentEffects of OTParent-child relationshipMaternal depression scoresChildren's early developmentSample of mothersCaregiving representationsChild OT levelsSalivary OTDepression scoresOT levelsMaternal-infant attachmentPlacebo-controlledDepressionTreatment “non-responders”: the experience of short-term psychoanalytic psychotherapy among depressed adolescents, their parents and therapists
Fiorini G, Khoe Z, Fonagy P, Midgley N. Treatment “non-responders”: the experience of short-term psychoanalytic psychotherapy among depressed adolescents, their parents and therapists. Frontiers In Psychology 2024, 15: 1389833. DOI: 10.3389/fpsyg.2024.1389833.Peer-Reviewed Original ResearchShort-term psychoanalytic psychotherapyPsychoanalytic psychotherapyShort-term psychotherapyTreatment non-responseEvidence-based treatmentsDepressed adolescentsPsychotherapyTherapy processShort-term treatmentYoung peopleTherapistsNon-respondersDescriptive-interpretive approachTreatment approachesNegative viewsAdolescentsNon-responseParentsPerspectives of young peopleDepressionPeopleSemi-structured interviewsStudy findingsFindingsPoor experienceBreaking the cycle with trauma-focused mentalization-based treatment: theory and practice of a trauma-focused group intervention
Smits M, de Vos J, Rüfenacht E, Nijssens L, Shaverin L, Nolte T, Luyten P, Fonagy P, Bateman A. Breaking the cycle with trauma-focused mentalization-based treatment: theory and practice of a trauma-focused group intervention. Frontiers In Psychology 2024, 15: 1426092. PMID: 39346509, PMCID: PMC11427379, DOI: 10.3389/fpsyg.2024.1426092.Peer-Reviewed Original ResearchMentalization-based treatmentImpact of traumaAdaptations of MBTGroup interventionBorderline personality pathologyTrauma-focused group interventionAttachment behavioral systemNegative perceptions of selfImpaired mental abilityClinical case examplesEffects of traumaPerceptions of selfPersonality pathologyAttachment traumaMental abilityMental perspectiveComplex traumaAvoidance behaviorEpistemic trustRelational difficultiesDissociative experiencesBehavioral systemsTreatment phaseCase examplePost-traumaMentalization-based interventions in schools for enhancing socio-emotional competencies and positive behaviour: a systematic review
Chelouche-Dwek G, Fonagy P. Mentalization-based interventions in schools for enhancing socio-emotional competencies and positive behaviour: a systematic review. European Child & Adolescent Psychiatry 2024, 1-21. PMID: 39264381, DOI: 10.1007/s00787-024-02578-5.Peer-Reviewed Original ResearchMental health outcomesMentalization-based interventionsNational Institutes of HealthHealth outcomesPositive mental health outcomesSystematic reviewInclusion criteriaMental health of childrenAged 6Heterogeneity of study designsQuality assessment toolSchool-based interventionsHealth of childrenStudents aged 6Lack of control groupsRisk of biasChildren aged 6Target age groupPeer-reviewed publicationsRandomized controlled trialsSocio-emotional competenciesSchool-aged childrenWeb of ScienceWell-designed randomized controlled trialsInstitutes of HealthMentalizing individuals, families and systems: Towards a translational socioecological approach
Luyten P, Malcorps S, Bateman A, Fonagy P. Mentalizing individuals, families and systems: Towards a translational socioecological approach. Psychology And Psychotherapy Theory Research And Practice 2024 PMID: 39239982, DOI: 10.1111/papt.12544.Peer-Reviewed Original ResearchMentalization-based treatmentMentalization-based approachBorderline personality disorderPersonality disorderEpistemic trustSocioecological approachMentalMental approachMental individualitySociocultural factorsClinical practiceIndividualsDisordersBorderlineSpectrum of interventionsResearchCentral focusInterventionTreatmentTrust under development: The Italian validation of the Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) for adolescents
Milesi A, Liotti M, Locati F, De Carli P, Speranza A, Campbell C, Fonagy P, Lingiardi V, Parolin L. Trust under development: The Italian validation of the Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) for adolescents. PLOS ONE 2024, 19: e0307229. PMID: 39186540, PMCID: PMC11346731, DOI: 10.1371/journal.pone.0307229.Peer-Reviewed Original ResearchConceptsSelf-report instrumentEpistemic trustContext of personality disordersConcept of epistemic trustDevelopment of mental disordersPersonality disorderEmotion dysregulationMeasure mentalizingMental disordersPsychological functioningItalian validationMental healthPsychopathologyAdolescent populationInterpersonal trustAdolescentsDisordersResearch contextEmpirical validationHigh schoolItalian adult populationAdult populationMentalQuestionnaireValidityHuman adolescent brain similarity development is different for paralimbic versus neocortical zones
Dorfschmidt L, Váša F, White S, Romero-García R, Kitzbichler M, Alexander-Bloch A, Cieslak M, Mehta K, Satterthwaite T, Consortium T, Bethlehem R, Seidlitz J, Vértes P, Bullmore E, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Kiddle B, Polek E, Fearon P, Suckling J, van Harmelen A, Kievit R, Chamberlain S, Bethlehem R. Human adolescent brain similarity development is different for paralimbic versus neocortical zones. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314074121. PMID: 39121162, PMCID: PMC11331068, DOI: 10.1073/pnas.2314074121.Peer-Reviewed Original ResearchConceptsMorphometric similarity networksFunctional connectivityNeocortical areasCortical areasFunctional MRI scansCourse of adolescenceAccelerated longitudinal designMagnetic resonance imagingStructure-function couplingCingulate cortexParalimbic areasInteroceptive functionAssociated with increased strengthIncreased hubnessFMRI networksStructural scansLongitudinal designCortical thinningDevelopment of human brainAdolescent developmentMorphometric similarityHealthy adolescentsAssociated with reduced strengthHuman brainCortexLinking mentalizing capacity, shame, and depressive symptoms in the context of childhood maltreatment
Schwarzer N, Nolte T, Fonagy P, Feigenbaum J, King-Casas B, Rüfenacht E, Gingelmaier S, Leibowitz J, Pilling S, Montague P, Network L. Linking mentalizing capacity, shame, and depressive symptoms in the context of childhood maltreatment. Children And Youth Services Review 2024, 163: 107787. DOI: 10.1016/j.childyouth.2024.107787.Peer-Reviewed Original ResearchExperiences of childhood maltreatmentFeelings of shameChildhood maltreatmentDepressive symptomsMental capacityContext of childhood maltreatmentNon-clinical participantsPredictors of depressive symptomsDomains of depressionCurrent depressive symptomsHistory of maltreatmentReducing depressive symptomsReduce feelings of shameSample of adultsMental health problemsPsychological treatmentStructural equation modelingMetacognitive processesCross-sectional designMaltreatmentMentalReduce feelingsShameImpairmentResults AssociationsWHO treatment guideline for mental disorders
Leichsenring F, Abbass A, Fonagy P, Levy K, Lilliengren P, Luyten P, Midgley N, Milrod B, Steinert C. WHO treatment guideline for mental disorders. The Lancet Psychiatry 2024, 11: 676-677. PMID: 39067469, DOI: 10.1016/s2215-0366(24)00169-x.Peer-Reviewed Original ResearchAlliance Rupture and Repair in Adolescent Psychotherapy: What Clinicians Can Learn From Research
Cirasola A, Fonagy P, Midgley N. Alliance Rupture and Repair in Adolescent Psychotherapy: What Clinicians Can Learn From Research. Psychotherapy 2024 PMID: 39023966, DOI: 10.1037/pst0000535.Peer-Reviewed Original ResearchAdolescent psychotherapyAlliance rupturesTraining of therapistsYouth psychotherapyTherapeutic alliancePositive allianceStronger allianceAdult therapyTherapeutic relationshipPsychotherapySymptom improvementTherapistsAlliance researchParental involvementAdolescentsRisky behaviorsAge groupsEnhance engagementPromote engagementYouthResistant to treatmentAllianceAlliance formationUnique challengesEngagementReducing self-harm in adolescents: the RISA-IPD individual patient data meta-analysis and systematic review
Cottrell D, Wright-Hughes A, Farrin A, Walwyn R, Mughal F, Truscott A, Diggins E, Irving D, Fonagy P, Ougrin D, Stahl D, Wright J. Reducing self-harm in adolescents: the RISA-IPD individual patient data meta-analysis and systematic review. Health Technology Assessment 2024, 1-42. PMID: 39024118, DOI: 10.3310/gtnt6331.Peer-Reviewed Original ResearchRepetition of self-harmNational Institute for Health and Care ResearchIndividual patient data meta-analysisPatient data meta-analysisData meta-analysisSelf-harmSample of participantsSystematic reviewMeta-analysisMeta-analysesPrimary outcomeRisk of bias assessmentLow risk of biasHistory of self-harmPreferred Reporting ItemsReduce self-harmRandomised controlled trialsRisk of biasConventional meta-analysesIndividual Patient DataCare researchPublic health concernEligible participantsClinical servicesIssues of research designExamination of a case of “treatment failure” in long-term psychoanalytic psychotherapy for treatment-resistant depression
Willemsen J, Rost F, Hustinx M, Fonagy P, Taylor D. Examination of a case of “treatment failure” in long-term psychoanalytic psychotherapy for treatment-resistant depression. The International Journal Of Psychoanalysis 2024, 105: 475-495. PMID: 39230487, DOI: 10.1080/00207578.2024.2352827.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionPsychoanalytic psychotherapyLong-term psychoanalytic psychotherapyLevels of depressionNegative therapeutic reactionExperiences of abandonmentPatients' levels of depressionStructured Clinical AssessmentPost-treatment outcomesTherapeutic relationshipPatterns of repetitionTherapy processTherapeutic reactionDepressionPsychic conflictPsychotherapyInternal worldInner worldClinical assessmentRandomized controlled trialsLack of symbolismDestructive patternsResearch contextInterpretive stanceTherapistsTraining and supervision of physical health professionals to implement mental health care in paediatric epilepsy clinics
Coughtrey A, Bennett S, Stanick C, Chorpita B, Dalrymple E, Fonagy P, Cross J, Ford T, Heyman I, Moss-Morris R, Team M, Shafran R. Training and supervision of physical health professionals to implement mental health care in paediatric epilepsy clinics. Epilepsy & Behavior 2024, 157: 109905. PMID: 38909460, DOI: 10.1016/j.yebeh.2024.109905.Peer-Reviewed Original ResearchPaediatric epilepsy servicesHealth professionalsMental health problemsSupervision sessionsPsychological interventionsHealth settingsClinical competenceChronic physical health conditionsDelivery of psychological interventionsEpilepsy servicesPhysical health settingsAcceptability of trainingHealth problemsTherapist competenceFace-to-face training workshopsMental health carePhysical health professionalsMental health settingsMental health interventionsMultiple mental health problemsPhysical health conditionsMental health backgroundPaediatric epilepsy clinicsRates of attendanceMeasures of therapist competenceMentalizing as a Predictor of Well-Being and Emotion Regulation: Longitudinal Evidence from a Community Sample of Young Adults.
Schwarzer N, Heim N, Gingelmaier S, Fonagy P, Nolte T. Mentalizing as a Predictor of Well-Being and Emotion Regulation: Longitudinal Evidence from a Community Sample of Young Adults. Psychological Reports 2024, 332941241261902. PMID: 38876977, DOI: 10.1177/00332941241261902.Peer-Reviewed Original ResearchNon-clinical sampleEmotion regulation strategiesPsychological symptom severityRegulation strategiesSymptom severityEmotional statesCommunity sample of young adultsAssociated with impaired psychological well-beingNon-clinical adult sampleWell-beingLongitudinal evidenceSample of young adultsAdaptive emotion regulationEffects of mentalizingYoung adultsProspective longitudinal designImpaired psychological well-beingIntense emotional statesPsychological well-beingIntentional mental statesMental health indicatorsCognitive reappraisalEmotion regulationCommunity sampleAdult samplesA machine-learning approach for differentiating borderline personality disorder from community participants with brain-wide functional connectivity
Lahnakoski J, Nolte T, Solway A, Vilares I, Hula A, Feigenbaum J, Lohrenz T, King-Casas B, Fonagy P, Montague P, Schilbach L. A machine-learning approach for differentiating borderline personality disorder from community participants with brain-wide functional connectivity. Journal Of Affective Disorders 2024, 360: 345-353. PMID: 38806064, DOI: 10.1016/j.jad.2024.05.125.Peer-Reviewed Original ResearchBorderline personality disorderPrediction of borderline personality disorderFunctional connectivityPersonality disorderBorderline personality disorder patientsBorderline personality disorder statusBrain-wide functional connectivityBiomarkers of psychiatric disordersFunctional connectivity markersFunctional connectivity patternsSelf-reported resultsClinical interviewPsychiatric disordersSomatomotor regionsChance levelSeed ROIConnectivity markersComparison correctionSeed regionConnectivity patternsDiscrimination performanceConnectivity valuesDisordersBorderlineGeneralizabilityCorrigendum: Epistemic trust and personality functioning mediate the association between adverse childhood experiences and posttraumatic stress disorder and complex posttraumatic stress disorder in adulthood
Kampling H, Kruse J, Lampe A, Nolte T, Hettich N, Brähler E, Sachser C, Fegert J, Gingelmaier S, Fonagy P, Krakau L, Zara S, Riedl D. Corrigendum: Epistemic trust and personality functioning mediate the association between adverse childhood experiences and posttraumatic stress disorder and complex posttraumatic stress disorder in adulthood. Frontiers In Psychiatry 2024, 15: 1427500. PMID: 38835551, PMCID: PMC11148657, DOI: 10.3389/fpsyt.2024.1427500.Peer-Reviewed Original ResearchA cross‐sectional investigation into the role of intersectionality as a moderator of the relation between youth adversity and adolescent depression/anxiety symptoms in the community
Havers L, Bhui K, Shuai R, Fonagy P, Fazel M, Morgan C, Fancourt D, McCrone P, Smuk M, Hosang G, Shakoor S. A cross‐sectional investigation into the role of intersectionality as a moderator of the relation between youth adversity and adolescent depression/anxiety symptoms in the community. Journal Of Adolescence 2024, 96: 1304-1315. PMID: 38769710, DOI: 10.1002/jad.12347.Peer-Reviewed Original ResearchDepression/anxiety symptomsMultiple group structural equation modelingGroup structural equation modelingLevels of depressionEmotional problems subscaleStrengths and Difficulties QuestionnaireIndication of moderationMental health problemsAssociated with higher levelsIntersectional effectsProblems subscaleStructural equation modelingCross-sectional designDifficulties QuestionnaireDepression/anxietyCross-sectional investigationAdversityModerating effectEquation modelingHigher SESPreliminary findingsStructural privilegeDisadvantaged individualsHealth problemsSymptomsClinical effectiveness and cost-effectiveness of a brief accessible cognitive behavioural therapy programme for stress in school-aged adolescents (BESST): a cluster randomised controlled trial in the UK
Brown J, James K, Lisk S, Shearer J, Byford S, Stallard P, Deighton J, Saunders D, Yarrum J, Fonagy P, Weaver T, Sclare I, Day C, Evans C, Carter B. Clinical effectiveness and cost-effectiveness of a brief accessible cognitive behavioural therapy programme for stress in school-aged adolescents (BESST): a cluster randomised controlled trial in the UK. The Lancet Psychiatry 2024, 11: 504-515. PMID: 38759665, DOI: 10.1016/s2215-0366(24)00101-9.Peer-Reviewed Original ResearchTreatment-as-usualCognitive behavioral therapyTreatment-as-usual groupCluster randomised controlled trialCognitive behavioral therapy workshopRandomised controlled trialsCognitive behavioural therapy programmeSymptoms of depressionBehavioural therapy programmePrimary intention-to-treat analysisSchools TrialIndex of Multiple DeprivationBehavioral therapyDepressive symptomsHealth Technology Assessment programmeSchool-aged adolescentsControlled trialsSelf-referral systemIntention-to-treat populationDiscover interventionsFull school yearMental healthDepressionTherapy programmeIntention-to-treat analysisBrief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics
James K, Lisk S, Payne-Cook C, Farishta Z, Farrelly M, Sheikh A, Slusarczyk M, Byford S, Day C, Deighton J, Evans C, Fonagy P, Saunders D, Sclare I, Shearer J, Stallard P, Weaver T, Yarrum J, Carter B, Brown J. Brief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics. Trials 2024, 25: 302. PMID: 38702825, PMCID: PMC11069277, DOI: 10.1186/s13063-024-08116-7.Peer-Reviewed Original ResearchConceptsSchool-based cluster randomised controlled trialWarwick-Edinburgh Mental Wellbeing ScaleCluster randomised controlled trialRandomised controlled trialsSchools TrialEducational workshopsMental Wellbeing ScaleControlled trialsOutcome data collectionSymptoms of depressionEthnic minority groupsSecondary schoolsReduce stigmaBaseline characteristicsPost-randomisationWellbeing ScaleSelf-referralSelf-referredLower wellbeingStudentsDistressed studentsEthnically diverse sampleSchoolWorkshop programmeGeneral wellbeing