2024
Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial
Fonagy P, Chammay R, Ngunu C, Kumar M, Verdeli L, Allison E, Anani G, Fearon P, Fouad F, Hoare Z, Koyio L, Moore H, Nyandigisi A, Pilling S, Sender H, Skordis J, Evans R, Jaoude G, Madeghe B, Maradian S, O’Donnell C, Simes E, Truscott A, Wambua G, Yator O. Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial. Trials 2024, 25: 217. PMID: 38532432, PMCID: PMC10964704, DOI: 10.1186/s13063-024-08039-3.Peer-Reviewed Original ResearchMeSH KeywordsDepressionDepression, PostpartumFemaleHumansKenyaLebanonPregnancyPsychotherapy, GroupWomen's HealthConceptsPostnatal depressionInterpersonal psychotherapyChild developmental outcomesMulti-site randomised controlled trialWomen's mental health needsStandard careEfficacy of interpersonal psychotherapyMaternal postnatal depressionMental health needsMental health concernsMiddle-income countriesRandomised controlled trialsDevelopmental outcomesHigh-income countriesAntenatal servicesChildbearing womenMother-child bondingRandomised superiority trialChildren's developmental progressHealth needsOffspring of womenMaternal depressionCommunity settingsLMIC contextsInterpersonal therapy
2021
Intranasal oxytocin administration improves mood in new mothers with moderate low mood but not in mothers with elevated symptoms of postnatal depression: A randomised controlled trial
Lindley Baron-Cohen K, Feldman R, Fearon P, Fonagy P. Intranasal oxytocin administration improves mood in new mothers with moderate low mood but not in mothers with elevated symptoms of postnatal depression: A randomised controlled trial. Journal Of Affective Disorders 2021, 300: 358-365. PMID: 34843839, DOI: 10.1016/j.jad.2021.11.062.Peer-Reviewed Original ResearchConceptsEdinburgh Postnatal Depression ScalePostnatal depressionOT administrationNew mothersLow moodPostnatal Depression ScaleCross-over designAntidepressant effectsMonths postpartumSevere scoresPND casesPND scoresSub-clinical levelsTreatment benefitDepression ScaleMood spectrumClinical diagnosisElevated symptomsAdministrationMood scoresMothersNegative moodWomenNeuropeptide hormoneDepressionMaternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation
Nazzari S, Fearon P, Rice F, Molteni M, Frigerio A. Maternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation. Journal Of Child Psychology And Psychiatry 2021, 63: 871-880. PMID: 34787327, DOI: 10.1111/jcpp.13532.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyDepressionDepression, PostpartumFemaleHumansHydrocortisoneInfantMaleMother-Child RelationsMothersPregnancySalivaStress, PsychologicalConceptsInfant stress regulationInfant cortisol reactivityC-reactive proteinMaternal sensitive caregivingAntenatal stressMaternal cortisolCortisol responseInfant stress response systemsInfant cortisol regulationMaternal antenatal stressMaternal caregivingInfant cortisol responseCortisol reactivityGreater cortisol responseAntenatal exposureMaternal ageMaternal levelsInterleukin-6Late pregnancyMaternal stress signalsPostnatal depressionSensitive caregivingAnimal studiesStress regulationCortisol regulation
2020
The biological underpinnings of perinatal depressive symptoms: A multi-systems approach.
Nazzari S, Fearon P, Rice F, Ciceri F, Molteni M, Frigerio A. The biological underpinnings of perinatal depressive symptoms: A multi-systems approach. Journal Of Affective Disorders 2020, 274: 1004-1012. PMID: 32663926, DOI: 10.1016/j.jad.2020.05.023.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesDepressionDepression, PostpartumFemaleHumansPregnancyPregnancy ComplicationsProspective StudiesSystems AnalysisConceptsPerinatal depressive symptomsC-reactive proteinDepressive symptomsLate pregnancyInterleukin-6Cortisol levelsHigher IL-6 levelsLower morning cortisol levelsEdinburgh Postnatal Depression ScaleAntenatal depressive symptomsStress-immune interactionsSerum interleukin-6IL-6 levelsDiurnal salivary cortisol levelsPostnatal Depression ScaleInflammatory response systemSalivary alpha-amylase levelsMorning cortisol levelsHigher depressive symptomsSalivary cortisol levelsBiological underpinningsAlpha-amylase levelsState-Trait Anxiety InventoryInflammatory biomarkersPerinatal depressionThe chronicity and timing of prenatal and antenatal maternal depression and anxiety on child outcomes at age 5
Hentges R, Graham S, Fearon P, Tough S, Madigan S. The chronicity and timing of prenatal and antenatal maternal depression and anxiety on child outcomes at age 5. Depression And Anxiety 2020, 37: 576-586. PMID: 32419282, DOI: 10.1002/da.23039.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyAnxiety DisordersChildChild, PreschoolDepressionDepression, PostpartumFemaleHumansMothersPregnancyPregnancy ComplicationsProspective StudiesConceptsDepression/anxietyMaternal depressionAge 5Maternal anxietyLarge prospective pregnancy cohortMaternal anxiety/depressionMaternal mental health problemsAntenatal maternal depressionProspective pregnancy cohortMaternal mental healthMother-child pairsClinical screening toolAnxiety/depressionChild outcomesMental health problemsWeeks' gestationPregnancy cohortYear postpartumPostpartum periodNumber of exposuresChild development outcomesDepression symptomsHealth problemsPoor child outcomesScreening tool
2017
Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress
Barry T, Murray L, Fearon P, Moutsiana C, Johnstone T, Halligan S. Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress. Psychoneuroendocrinology 2017, 85: 96-99. PMID: 28843903, PMCID: PMC5632999, DOI: 10.1016/j.psyneuen.2017.07.487.Peer-Reviewed Original ResearchConceptsAmygdala volumePostnatal depressionMaternal postnatal depressionTotal amygdala volumeCortisol reactivityAdrenal (HPA) axis reactivityLower cortisol reactivityAdrenal axisCortisol secretionControl offspringAxis reactivityYoung adultsAmygdalaEarly adversityStress reactivitySocial stressSocial stressorsPresent studyEmotional processingEmotional pathologyOffspringCentral rolePathologyHierarchical linear modellingBrain
2016
Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers
Macdonald B, Murray L, Moutsiana C, Fearon P, Cooper P, Halligan S, Johnstone T. Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers. Biological Psychology 2016, 118: 147-153. PMID: 27208693, PMCID: PMC4962770, DOI: 10.1016/j.biopsycho.2016.05.006.Peer-Reviewed Original ResearchConceptsLateral prefrontal cortexAutobiographical memoryPrefrontal cortexEmotional autobiographical memoriesRight middle frontal gyrusMaternal depressionPleasant autobiographical memoriesAutobiographical memory systemAutobiographical memory networkPosterior brain regionsMiddle temporal gyrusMiddle frontal gyrusRight frontal poleAutobiographical recallAltered engagementRecordings of participantsPositive situationsLateral prefrontalPrefrontal regulationFrontal gyrusGreater activationNeural mechanismsPND mothersTemporal gyrusNegative situations
2014
Parenting difficulties and postnatal depression: implications for primary healthcare assessment and intervention.
Murray L, Cooper P, Fearon P. Parenting difficulties and postnatal depression: implications for primary healthcare assessment and intervention. Community Practitioner : The Journal Of The Community Practitioners' & Health Visitors' Association 2014, 87: 34-8. PMID: 25612413.Peer-Reviewed Original ResearchConceptsChild outcomesPoor cognitive developmentCognitive developmentPostnatal depressionDomain-specific associationsExternalising behaviour problemsMother-child relationshipChild's developmental stageAdverse child outcomesHostile parentingNon-depressed mothersInsecure attachmentParental difficultiesEmotional vulnerabilityInfant signsInfant distressMaternal insensitivityBehavior problemsExternalising problemsSet of assessmentsParentingChildren of mothersImpairmentDepressionChildrenInsecure attachment during infancy predicts greater amygdala volumes in early adulthood
Moutsiana C, Johnstone T, Murray L, Fearon P, Cooper P, Pliatsikas C, Goodyer I, Halligan S. Insecure attachment during infancy predicts greater amygdala volumes in early adulthood. Journal Of Child Psychology And Psychiatry 2014, 56: 540-548. PMID: 25156392, PMCID: PMC4407912, DOI: 10.1111/jcpp.12317.Peer-Reviewed Original ResearchConceptsAmygdala volumeGreater amygdala volumesMaternal postnatal depressionLarger amygdala volumesInfant attachment statusProspective longitudinal studyLongitudinal studyMonths of ageMaternal depression historyAmygdala morphologyMRI assessmentHippocampal volumePostnatal depressionAdult brainDepression historyNeural changesEarly environmentEarly caregiving environmentAttachment statusVolumetric differencesYoung adultsEarly adulthoodNeural areasCaregiving environmentCommon variation
2011
Maternal Postnatal Depression and the Development of Depression in Offspring Up to 16 Years of Age
Murray L, Arteche A, Fearon P, Halligan S, Goodyer I, Cooper P. Maternal Postnatal Depression and the Development of Depression in Offspring Up to 16 Years of Age. Journal Of The American Academy Of Child & Adolescent Psychiatry 2011, 50: 460-470. PMID: 21515195, DOI: 10.1016/j.jaac.2011.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild of Impaired ParentsChild, PreschoolDepression, PostpartumDepressive Disorder, MajorDysthymic DisorderFamily ConflictFemaleHumansInfantInterview, PsychologicalLife Change EventsLongitudinal StudiesMaleMass ScreeningObject AttachmentProspective StudiesResilience, PsychologicalRisk FactorsSocial SupportConceptsYears of ageDepressed mothersPostnatal depressionClinical depressionAdolescent depressionFamily adversityMain study outcomeMaternal postnatal depressionDevelopment of depressionProspective longitudinal studyDevelopmental risk pathwayIndex mothersOffspring riskProbable casesNondepressed mothersStudy outcomesChild vulnerabilityInsecure infant attachmentDepressionMothersLongitudinal studyRisk pathwaysFamily assessmentDevelopmental riskRisk
2010
The effects of maternal postnatal depression and child sex on academic performance at age 16 years: a developmental approach
Murray L, Arteche A, Fearon P, Halligan S, Croudace T, Cooper P. The effects of maternal postnatal depression and child sex on academic performance at age 16 years: a developmental approach. Journal Of Child Psychology And Psychiatry 2010, 51: 1150-1159. PMID: 20840504, DOI: 10.1111/j.1469-7610.2010.02259.x.Peer-Reviewed Original ResearchConceptsCognitive functioningMother-child interactionStructural equation modellingPostnatal depressionChild sexChildren's cognitive functioningMaternal depressionPoor cognitive functioningEarly school yearsNon-depressed mothersCognitive developmentMaternal postnatal depressionPND mothersAcademic outcomesDevelopmental approachMaternal interactionAcademic performanceGCSE performanceEquation modellingControl childrenSchool yearFunctioningEarly interventionExam performanceAge 16 years