2015
Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus.
Romerowicz-Misielak M, Oren D, Sowa-Kucma M, Tabecka-Lonczynska A, Gilun P, Stefanczyk-Krzymowska S, Koziorowski M. Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus. Journal Of Physiology And Pharmacology 2015, 66: 505-14. PMID: 26348075.Peer-Reviewed Original ResearchConceptsOphthalmic venous bloodVenous bloodNocturnal melatonin riseMelatonin levelsMelatonin riseWinter seasonal affective disorderNocturnal melatonin peakSeasonal affective disorderHour infusionCavernous sinusVenous sinusesNon-physiological changesAutologous blood plasmaAffective disordersSynthesis of melatoninBright light effectsBloodAANAT protein levelsMelatonin peakProtein levelsAcute impactSinusTreatmentBlood plasmaParallel changes
1996
Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder
Oren D, Levendosky A, Kasper S, Duncan C, Rosenthal N. Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder. Biological Psychiatry 1996, 39: 157-170. PMID: 8837977, DOI: 10.1016/0006-3223(95)00079-8.Peer-Reviewed Original Research
1994
1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: Effects of light
Oren D, Schulkin J, Rosenthal N. 1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: Effects of light. Psychopharmacology 1994, 116: 515-516. PMID: 7701056, DOI: 10.1007/bf02247486.Peer-Reviewed Original ResearchConceptsVitamin D3 levelsSeasonal affective disorderD3 levelsAffective disordersGender-matched controlsWinter seasonal affective disorderLight therapyDisordersA controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder
Oren D, Teicher M, Schwartz P, Glod C, Turner E, Ito Y, Sedway J, Rosenthal N, Wehr T. A controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder. Journal Of Affective Disorders 1994, 32: 197-200. PMID: 7852661, DOI: 10.1016/0165-0327(94)90018-3.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderAffective disordersEffective short-term treatmentWeekly outpatient visitsShort-term treatmentSIGH-SAD scoresPlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodEffective treatmentSame scheduleVitamin B12SAD patientsSignificant differencesTreatmentPatientsWeeksDisordersCyanocobalaminRandom assignmentPlaceboTrialsVisitsPlatelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder
Ozaki N, Rosenthal N, Mazzola P, Chiueh C, Hardin T, Garcia-Borreguero D, Schwartz P, Turner E, Oren D, Murphy D. Platelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder. Biological Psychiatry 1994, 36: 458-466. PMID: 7811842, DOI: 10.1016/0006-3223(94)90641-6.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderSAD patientsAffective disordersBrain serotonergic systemSerotonergic measuresSerotonergic abnormalitiesSerotonergic functionDensity-dependent subpopulationsPlatelet turnoverSerotonergic systemPatientsReceptor functionNeurotransmitter aminesTherapy conditionsHigher BmaxLight plateletsPlateletsDisordersPresent studyHeavy plateletsCa2SerotoninA Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder
OREN D, MOUL D, SCHWARTZ P, WEHR T, ROSENTHAL N. A Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder. Journal Of Clinical Psychopharmacology 1994, 14: 196-200. PMID: 8027416, DOI: 10.1097/00004714-199406000-00007.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderDopaminergic deficiencyAffective disordersItem Hamilton Rating ScaleEfficacy of levodopaUse of levodopaWeekly outpatient visitsHamilton Rating ScalePlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodRate of responseDepression scoresPatientsLevodopaPlaceboCarbidopaRating ScaleIdentical scheduleSAD patientsTreatmentWeeksDisordersExposure to ambient light in patients with winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Brown C, Yamada E, Rosenthal N. Exposure to ambient light in patients with winter seasonal affective disorder. American Journal Of Psychiatry 1994, 151: 591-593. PMID: 8147459, DOI: 10.1176/ajp.151.4.591.Peer-Reviewed Original ResearchConceptsWinter seasonal affective disorderSeasonal affective disorderAffective disordersSeverity of depressionNormal comparison subjectsMorning light exposureNormal subjectsComparison subjectsGreater severityPatientsDepressionDisordersExposure profilesSeverityExposureLight exposureSubjectsShort photoperiodOutpatientsLight monitorWeeks
1993
Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder
Ozaki N, Rosenthal N, Moul D, Schwartz P, Oren D. Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder. Psychiatry Research 1993, 49: 99-107. PMID: 8153191, DOI: 10.1016/0165-1781(93)90098-2.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderControl subjectsLight therapyEOG ratiosSAD patientsAffective disordersEffect of phototherapyNormal control subjectsWinter seasonal affective disorderRetinal abnormalitiesPatientsConfounding factorsEOG testingTherapyDisordersSubjectsTest variabilityOutpatientsAbnormalitiesPhototherapySpontaneous eye blink rate in winter seasonal affective disorder
Barbato G, Moul D, Schwartz P, Rosenthal N, Oren D. Spontaneous eye blink rate in winter seasonal affective disorder. Psychiatry Research 1993, 47: 79-85. PMID: 8516420, DOI: 10.1016/0165-1781(93)90057-n.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderNormal control subjectsSpontaneous eye blink rateWinter seasonal affective disorderEye blink rateControl subjectsLight therapyBlink rateAffective disordersPremenopausal female subjectsSAD patientsDrug-free patientsElevated blink ratePatientsBiological markersFemale subjectsSignificant decreaseSignificant differencesTherapyDisordersSignificant changesPossible linkSubjectsTreatmentExploratory analysisA Multicenter Study of the Light Visor for Seasonal Affective Disorder: No Difference in Efficacy Found Between Two Different Intensities
Rosenthal N, Moul D, Hellekson C, Oren D, Frank A, Brainard G, Murray M, Wehr T. A Multicenter Study of the Light Visor for Seasonal Affective Disorder: No Difference in Efficacy Found Between Two Different Intensities. Neuropsychopharmacology 1993, 8: 151-160. PMID: 8471127, DOI: 10.1038/npp.1993.17.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderLight visorAffective disordersWinter seasonal affective disorderMulticenter studyTreatment sessionsGreater relapseResponse rateParallel designAn investigation of ophthalmic function in winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Alexander J, Yatnada E, Rosenthal N. An investigation of ophthalmic function in winter seasonal affective disorder. Depression 1993, 1: 29-37. DOI: 10.1002/depr.3050010107.Peer-Reviewed Original ResearchSeasonal affective disorderWinter seasonal affective disorderAffective disordersFarnsworth-Munsell 100 hue testFunction testsIntraocular pressurePattern electroretinogramPupillary sizeLight therapyApplanation tonometerNormal controlsVisual functioningP100 componentB-wave componentHue testOphthalmic functionNeurological pathwaysOphthalmic defectsSignificant differencesPatientsDark adaptationWiley-LissColor visionDisordersLittle evidence
1991
Adaptation to dim light in depressed patients with seasonal affective disorder
Oren D, Joseph-Vanderpool J, Rosenthal N. Adaptation to dim light in depressed patients with seasonal affective disorder. Psychiatry Research 1991, 36: 187-193. PMID: 2017533, DOI: 10.1016/0165-1781(91)90130-h.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderAffective disordersDrug-free healthy controlsSAD patientsManic-depressive illnessWinter seasonal affective disorderPossible trait markerDepressed SAD patientsDepressive episodeDepressed patientsHealthy controlsDark adaptation curvePatientsTrait markerDiminished sensitivityDisordersSupersensitivity