2015
Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus.
Romerowicz-Misielak M, Oren D, Sowa-Kucma M, Tabecka-Lonczynska A, Gilun P, Stefanczyk-Krzymowska S, Koziorowski M. Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus. Journal Of Physiology And Pharmacology 2015, 66: 505-14. PMID: 26348075.Peer-Reviewed Original ResearchConceptsOphthalmic venous bloodVenous bloodNocturnal melatonin riseMelatonin levelsMelatonin riseWinter seasonal affective disorderNocturnal melatonin peakSeasonal affective disorderHour infusionCavernous sinusVenous sinusesNon-physiological changesAutologous blood plasmaAffective disordersSynthesis of melatoninBright light effectsBloodAANAT protein levelsMelatonin peakProtein levelsAcute impactSinusTreatmentBlood plasmaParallel changes
2006
Tyramine Pressor Sensitivity During Treatment With the Selegiline Transdermal System 6 mg/24 h in Healthy Subjects
Azzaro A, VanDenBerg C, Blob L, Kemper E, Sharoky M, Oren D, Campbell B. Tyramine Pressor Sensitivity During Treatment With the Selegiline Transdermal System 6 mg/24 h in Healthy Subjects. The Journal Of Clinical Pharmacology 2006, 46: 933-944. PMID: 16855078, DOI: 10.1177/0091270006289852.Peer-Reviewed Original ResearchConceptsSelegiline transdermal systemTyramine sensitivity factorTransdermal systemOral tyramine pressor testDietary tyramine restrictionsTyramine pressor testTyramine pressor sensitivityDays of treatmentPressor dosesPressor sensitivityPressor testTranylcypromine treatmentHealthy malesHealthy subjectsHigh doseRatio of baselineExtended treatmentTreatmentCapsuleDaysCoadministrationSafety marginFactorsDoseDoses
2001
Is Seasonal Affective Disorder a Disorder of Circadian Rhythms?
Desan P, Oren D. Is Seasonal Affective Disorder a Disorder of Circadian Rhythms? CNS Spectrums 2001, 6: 487-501. PMID: 15744212, DOI: 10.1017/s1092852900008038.Peer-Reviewed Original Research
2000
Antidepressant effects of ketamine in depressed patients
Berman R, Cappiello A, Anand A, Oren D, Heninger G, Charney D, Krystal J. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 2000, 47: 351-354. PMID: 10686270, DOI: 10.1016/s0006-3223(99)00230-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsDepressive Disorder, MajorDose-Response Relationship, DrugDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleGlutamic AcidHumansInjections, IntravenousKetamineMaleMiddle AgedPsychiatric Status Rating ScalesReceptors, N-Methyl-D-AspartateSeverity of Illness IndexConceptsMajor depressionN-methyl-D-aspartate receptor antagonistBrain glutamate systemDouble-blind trialDouble-blind conditionsTreatment of depressionMechanism of actionPlacebo infusionAntidepressant effectsIntravenous treatmentSingle doseReceptor antagonistDepressed patientsGlutamate systemDepressive symptomsPreclinical researchKetamine hydrochlorideDepressionPotential roleTest dayTreatment effectsPatientsKetamineSaline solutionTreatment
1998
Carbon monoxide poisoning and treatment with hyperbaric oxygen in the subacute phase
Coric V, Oren D, Wolkenberg F, Kravitz R. Carbon monoxide poisoning and treatment with hyperbaric oxygen in the subacute phase. Journal Of Neurology Neurosurgery & Psychiatry 1998, 65: 245. PMID: 9703180, PMCID: PMC2170185, DOI: 10.1136/jnnp.65.2.245.Peer-Reviewed Original ResearchConceptsHyperbaric oxygenCarbon monoxide poisoningPatient underwent treatmentAnterograde memory lossCarbon monoxide intoxicationCarbon monoxide exposureAcute confusionNeuropsychiatric functionSubacute phaseSymptom reliefUnderwent treatmentClinical findingsNormobaric oxygenImmediate treatmentBrain injuryTherapeutic windowNeuropsychological testingMatter of debateMemory lossPartial retrogradeTreatmentMonthsPoisoningNormobaricPatients
1994
A controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder
Oren D, Teicher M, Schwartz P, Glod C, Turner E, Ito Y, Sedway J, Rosenthal N, Wehr T. A controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder. Journal Of Affective Disorders 1994, 32: 197-200. PMID: 7852661, DOI: 10.1016/0165-0327(94)90018-3.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderAffective disordersEffective short-term treatmentWeekly outpatient visitsShort-term treatmentSIGH-SAD scoresPlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodEffective treatmentSame scheduleVitamin B12SAD patientsSignificant differencesTreatmentPatientsWeeksDisordersCyanocobalaminRandom assignmentPlaceboTrialsVisitsA Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder
OREN D, MOUL D, SCHWARTZ P, WEHR T, ROSENTHAL N. A Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder. Journal Of Clinical Psychopharmacology 1994, 14: 196-200. PMID: 8027416, DOI: 10.1097/00004714-199406000-00007.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderDopaminergic deficiencyAffective disordersItem Hamilton Rating ScaleEfficacy of levodopaUse of levodopaWeekly outpatient visitsHamilton Rating ScalePlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodRate of responseDepression scoresPatientsLevodopaPlaceboCarbidopaRating ScaleIdentical scheduleSAD patientsTreatmentWeeksDisorders
1993
Spontaneous eye blink rate in winter seasonal affective disorder
Barbato G, Moul D, Schwartz P, Rosenthal N, Oren D. Spontaneous eye blink rate in winter seasonal affective disorder. Psychiatry Research 1993, 47: 79-85. PMID: 8516420, DOI: 10.1016/0165-1781(93)90057-n.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderNormal control subjectsSpontaneous eye blink rateWinter seasonal affective disorderEye blink rateControl subjectsLight therapyBlink rateAffective disordersPremenopausal female subjectsSAD patientsDrug-free patientsElevated blink ratePatientsBiological markersFemale subjectsSignificant decreaseSignificant differencesTherapyDisordersSignificant changesPossible linkSubjectsTreatmentExploratory analysisLight visor treament for seasonal affective disorder: A multicenter study
Joffe R, Moul D, Lam R, Levitt A, Teicher M, Lebegue B, Oren D, Buchanan A, Glod C, Murray M, Brown J, Schwartz P. Light visor treament for seasonal affective disorder: A multicenter study. Psychiatry Research 1993, 46: 29-39. PMID: 8464953, DOI: 10.1016/0165-1781(93)90005-2.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderAntidepressant responseLight therapyAffective disordersTreatment of SADSeverity of depressionAntidepressant actionAntidepressant efficacyMulticenter studyMedication statusNonspecific effectsSimilar frequencySignificant differencesTherapyParallel designDisordersTreatmentPrevious studies
1991
Usage patterns of phototherapy in seasonal affective disorder
Oren D, Shannon N, Carpenter C, Rosenthal N. Usage patterns of phototherapy in seasonal affective disorder. Comprehensive Psychiatry 1991, 32: 147-152. PMID: 2022114, DOI: 10.1016/0010-440x(91)90007-y.Peer-Reviewed Original Research