2013
SAD and the Not-So-Single Photoreceptors
Oren DA, Koziorowski M, Desan PH. SAD and the Not-So-Single Photoreceptors. American Journal Of Psychiatry 2013, 170: 1403-1412. PMID: 23929223, DOI: 10.1176/appi.ajp.2013.13010111.Peer-Reviewed Original ResearchConceptsMolecular mechanismsSeasonal affective disorderCircannual regulationCritical regulatorTetrapyrrole pigmentsDevelopment of therapiesRole of rodsInfluence of lightPhotoreceptorsCone photoreceptorsLight treatmentAntidepressant effectsPhysiologyAnimal modelsAffective disordersRecent studiesSingle photoreceptorsPhototransductionRegulatorDisordersRegulationMechanismGasotransmitterRolePigments
1997
Bilirubin, Rem Sleep, and Phototransduction of Environmental Time Cues. A Hypothesis
Oren D. Bilirubin, Rem Sleep, and Phototransduction of Environmental Time Cues. A Hypothesis. Chronobiology International 1997, 14: 319-329. PMID: 9167892, DOI: 10.3109/07420529709001423.Peer-Reviewed Original ResearchConceptsBiological clockEndogenous biological clockPlant phytochromesEvolutionary roleBiological clock systemEnvironmental time cuesDifferent speciesZeitgeber signalsClock systemVisual pigmentsHeme moietyCommon molecular structurePrimary effectPhototransductionBiological rhythmsPlantsPrevailing hypothesisPigmentsSimilar chromophoresTime cuesClockAnimalsPhytochromeSpeciesBile pigments