Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor
Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews P, Cowen P. Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor. American Journal Of Psychiatry 2004, 161: 368-370. PMID: 14754790, DOI: 10.1176/appi.ajp.161.2.368.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA concentrationsAcute administrationGABA concentrationSelective serotonin reuptake inhibitor citalopramSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitor citalopramCortical gamma-aminobutyric acidActions of SSRIsGABA/creatine ratiosReuptake inhibitor citalopramSerotonin reuptake inhibitorsGABA neuronsSSRI treatmentReuptake inhibitorsIntravenous citalopramDepressed patientsCreatine ratioHealthy volunteersCortical levelOccipital cortexCrossover designMean increaseMagnetic resonance spectroscopyMood improvement