2003
Contrasting effects of citalopram and reboxetine on waking salivary cortisol
Harmer C, Bhagwagar Z, Shelley N, Cowen P. Contrasting effects of citalopram and reboxetine on waking salivary cortisol. Psychopharmacology 2003, 167: 112-114. PMID: 12605289, DOI: 10.1007/s00213-003-1417-y.Peer-Reviewed Original ResearchConceptsHPA axis activitySalivary cortisolAxis activitySelective noradrenaline re-uptake inhibitorNoradrenaline re-uptake inhibitorSelective serotonin re-uptake inhibitor citalopramConclusionsShort-term treatmentDifferent antidepressant medicationsHPA axis functionEffect of citalopramRe-uptake inhibitorsDouble-blind designShort-term treatmentBasal salivary cortisol levelsDiurnal salivary cortisolSalivary free cortisolSalivary cortisol levelsAntidepressant administrationRationaleAcute administrationReboxetine treatmentAntidepressant medicationAntidepressant treatmentAxis functionHPA axisAdrenal axis
2001
PET measurement of the influence of corticosteroids on serotonin-1A receptor number
Montgomery A, Bench C, Young A, Hammers A, Gunn R, Bhagwagar Z, Grasby P. PET measurement of the influence of corticosteroids on serotonin-1A receptor number. Biological Psychiatry 2001, 50: 668-676. PMID: 11704073, DOI: 10.1016/s0006-3223(01)01205-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Inflammatory AgentsBinding, CompetitiveDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleHippocampusHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemReceptors, SerotoninReceptors, Serotonin, 5-HT1Tomography, Emission-ComputedConceptsPositron emission tomographyReceptor numberReceptor bindingPlacebo-controlled designInfluence of corticosteroidsSingle doseSerotonergic systemPreclinical studiesCorticosteroidsNormal subjectsModulatory effectsAlters 5Corticosteroid levelsBrain regionsEmission tomographyElevated levelsPET measurementsHippocampusHuman brainPatientsHydrocortisoneDoseBrainReceptors
2000
Modelling a loss event: effect of imagined bereavement on the hypothalamic–pituitary–adrenal axis
McCLEERY J, BHAGWAGAR Z, SMITH K, GOODWIN G, COWEN P. Modelling a loss event: effect of imagined bereavement on the hypothalamic–pituitary–adrenal axis. Psychological Medicine 2000, 30: 219-223. PMID: 10722192, DOI: 10.1017/s0033291799001361.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectBereavementFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemImaginationMaleMiddle AgedModels, PsychologicalPituitary-Adrenal SystemSalivaStress, PsychologicalConceptsNegative mood induction procedureNegative mood inductionMood induction procedureMood inductionRelevant psychosocial stressorsIndividual differencesCortisol responseSalivary cortisol responseTransient moodPsychological stateInduction procedureAcute cortisol responsePsychosocial stressorsMood disorders researchDisorder researchCortisol outputStressorsBereavementNeuroendocrine responsesMoodAdrenal axisDepressive illnessHealthy volunteersMusicImportant mediator