2004
Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor
Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews P, Cowen P. Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor. American Journal Of Psychiatry 2004, 161: 368-370. PMID: 14754790, DOI: 10.1176/appi.ajp.161.2.368.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA concentrationsAcute administrationGABA concentrationSelective serotonin reuptake inhibitor citalopramSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitor citalopramCortical gamma-aminobutyric acidActions of SSRIsGABA/creatine ratiosReuptake inhibitor citalopramSerotonin reuptake inhibitorsGABA neuronsSSRI treatmentReuptake inhibitorsIntravenous citalopramDepressed patientsCreatine ratioHealthy volunteersCortical levelOccipital cortexCrossover designMean increaseMagnetic resonance spectroscopyMood improvementNormalization of Enhanced Fear Recognition by Acute SSRI Treatment in Subjects With a Previous History of Depression
Bhagwagar Z, Cowen P, Goodwin G, Harmer C. Normalization of Enhanced Fear Recognition by Acute SSRI Treatment in Subjects With a Previous History of Depression. American Journal Of Psychiatry 2004, 161: 166-168. PMID: 14702268, DOI: 10.1176/appi.ajp.161.1.166.Peer-Reviewed Original Research
2003
Contrasting effects of citalopram and reboxetine on waking salivary cortisol
Harmer C, Bhagwagar Z, Shelley N, Cowen P. Contrasting effects of citalopram and reboxetine on waking salivary cortisol. Psychopharmacology 2003, 167: 112-114. PMID: 12605289, DOI: 10.1007/s00213-003-1417-y.Peer-Reviewed Original ResearchConceptsHPA axis activitySalivary cortisolAxis activitySelective noradrenaline re-uptake inhibitorNoradrenaline re-uptake inhibitorSelective serotonin re-uptake inhibitor citalopramConclusionsShort-term treatmentDifferent antidepressant medicationsHPA axis functionEffect of citalopramRe-uptake inhibitorsDouble-blind designShort-term treatmentBasal salivary cortisol levelsDiurnal salivary cortisolSalivary free cortisolSalivary cortisol levelsAntidepressant administrationRationaleAcute administrationReboxetine treatmentAntidepressant medicationAntidepressant treatmentAxis functionHPA axisAdrenal axisAcute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
Harmer C, Bhagwagar Z, Perrett D, Völlm B, Cowen P, Goodwin G. Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers. Neuropsychopharmacology 2003, 28: 148-152. PMID: 12496951, DOI: 10.1038/sj.npp.1300004.Peer-Reviewed Original ResearchConceptsEmotional processingFacial expressionsFacial expression recognition taskExpression recognition taskAcute SSRI administrationBasic emotionsSocial cuesEmotional intensityNeural processesSocial informationRecognition taskEarly acute effectsReduced response timeEmotional standardsSubjective experienceSocial behaviorTesting sessionsSSRI administrationAcute administrationMoodSelective serotonin reuptake inhibitorsProcessingSerotonin reuptake inhibitorsRole of serotoninHealthy female volunteers
2002
Acute administration of citalopram facilitates memory consolidation in healthy volunteers
Harmer C, Bhagwagar Z, Cowen P, Goodwin G. Acute administration of citalopram facilitates memory consolidation in healthy volunteers. Psychopharmacology 2002, 163: 106-110. PMID: 12185407, DOI: 10.1007/s00213-002-1151-x.Peer-Reviewed Original ResearchConceptsMemory consolidationCognitive actionsLong-term memory performanceAuditory Verbal Learning TestRecall/recognitionVerbal Learning TestVerbal memory testsSustained attention performanceFacilitate memory consolidationAttention performanceMemory testImmediate recallLearning TestMemory performanceCognitive functionMemory deficitsInformation processingGroups of subjectsSerotonergic neurotransmissionGroup designRecallNon-specific increaseSuccessful pharmacological treatmentDepressed patientsSymptom improvementAcute citalopram administration produces correlated increases in plasma and salivary cortisol
Bhagwagar Z, Hafizi S, Cowen P. Acute citalopram administration produces correlated increases in plasma and salivary cortisol. Psychopharmacology 2002, 163: 118-120. PMID: 12185409, DOI: 10.1007/s00213-002-1149-4.Peer-Reviewed Original ResearchConceptsSalivary cortisol levelsCortisol levelsSelective serotonin re-uptake inhibitorsSalivary cortisolSerotonin re-uptake inhibitorsAcute citalopram administrationRe-uptake inhibitorsCross-over designSalivary cortisol concentrationsCitalopram administrationIntravenous administrationCortisol releaseHealthy volunteersCortisol concentrationsSaliva cortisolCitalopramCortisolParallel increaseAdministrationCorrelated increaseAcceptable meansState and trait abnormalities in serotonin function in major depression
Bhagwagar Z, Whale R, Cowen P. State and trait abnormalities in serotonin function in major depression. The British Journal Of Psychiatry 2002, 180: 24-28. PMID: 11772847, DOI: 10.1192/bjp.180.1.24.Peer-Reviewed Original ResearchConceptsCortisol responseHealthy controlsMajor depressionSerotonin functionRecovered subjectsAdrenal axis dysfunctionBrain serotonin functionPlacebo-controlled designMarker of vulnerabilityAxis dysfunctionClinical recoveryReuptake inhibitorsUnmedicated subjectsProlactin responseDepressed patientsEndocrine responsesNeuroendocrine studiesDepressed subjectsCitalopramDepressionPatientsSubjectsResponseDysfunctionNeurotransmission