2005
Increased salivary cortisol after waking in depression
Bhagwagar Z, Hafizi S, Cowen P. Increased salivary cortisol after waking in depression. Psychopharmacology 2005, 182: 54-57. PMID: 15991000, DOI: 10.1007/s00213-005-0062-z.Peer-Reviewed Original ResearchConceptsSalivary cortisolMedication-free subjectsMorning cortisol secretionCommunity-based sampleExaggerated releaseCortisol secretionAcute depressionHealthy controlsMajor depressionCortisol levelsDepressed subjectsCortisolMore cortisolDepressionPatientsRecent studiesSubjectsHypersecretionPathophysiologyObjectiveToMinMethodsWeResultsInControlSecretion
2002
State and trait abnormalities in serotonin function in major depression
Bhagwagar Z, Whale R, Cowen P. State and trait abnormalities in serotonin function in major depression. The British Journal Of Psychiatry 2002, 180: 24-28. PMID: 11772847, DOI: 10.1192/bjp.180.1.24.Peer-Reviewed Original ResearchConceptsCortisol responseHealthy controlsMajor depressionSerotonin functionRecovered subjectsAdrenal axis dysfunctionBrain serotonin functionPlacebo-controlled designMarker of vulnerabilityAxis dysfunctionClinical recoveryReuptake inhibitorsUnmedicated subjectsProlactin responseDepressed patientsEndocrine responsesNeuroendocrine studiesDepressed subjectsCitalopramDepressionPatientsSubjectsResponseDysfunctionNeurotransmission