2009
Enhanced Visual Motion Perception in Major Depressive Disorder
Golomb JD, McDavitt JR, Ruf BM, Chen JI, Saricicek A, Maloney KH, Hu J, Chun MM, Bhagwagar Z. Enhanced Visual Motion Perception in Major Depressive Disorder. Journal Of Neuroscience 2009, 29: 9072-9077. PMID: 19605644, PMCID: PMC2772577, DOI: 10.1523/jneurosci.1003-09.2009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceContrast SensitivityDepressive Disorder, MajorDiscrimination LearningDiscrimination, PsychologicalHumansMotion PerceptionNeuropsychological TestsOrientationPattern Recognition, VisualPhotic StimulationPsychophysicsReaction TimeSensory ThresholdsVisual AcuityYoung AdultConceptsSpatial suppressionMotion perceptionLarge high-contrast stimuliMotion discrimination taskVisual motion perceptionMajor depressive disorderGreater lifetime durationHigh-contrast stimuliPerceptual discriminationHealthy young adultsVisual processingDiscrimination taskTime of testingTrait vulnerabilityPsychophysical performanceCounterintuitive hypothesisEndophenotypic markerVisual systemProcessing tasksMood symptomsOccipital cortexDepressive disorderYoung adultsVisual pathwayCortical level
2004
Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor
Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews P, Cowen P. Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor. American Journal Of Psychiatry 2004, 161: 368-370. PMID: 14754790, DOI: 10.1176/appi.ajp.161.2.368.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA concentrationsAcute administrationGABA concentrationSelective serotonin reuptake inhibitor citalopramSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitor citalopramCortical gamma-aminobutyric acidActions of SSRIsGABA/creatine ratiosReuptake inhibitor citalopramSerotonin reuptake inhibitorsGABA neuronsSSRI treatmentReuptake inhibitorsIntravenous citalopramDepressed patientsCreatine ratioHealthy volunteersCortical levelOccipital cortexCrossover designMean increaseMagnetic resonance spectroscopyMood improvement