2020
MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression
Bruschetta G, Jin S, Liu ZW, Kim JD, Diano S. MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression. Cell Reports 2020, 33: 108267. PMID: 33053350, DOI: 10.1016/j.celrep.2020.108267.Peer-Reviewed Original ResearchConceptsDorsal raphe nucleusNeuronal activationR neuronsDepressive-like behaviorMajor depressive disorderChemogenetic activationR miceChemogenetic inhibitionRaphe nucleusSerotonin levelsDepressive disorderMood behaviorΑ-MSHDRN infusionsControl feedingMiceWeight lossNeuronsSelective knockdownDepressionBehavioral phenotypesAnxietyActivationFeedingPRCP
2014
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 2014, 17: 908-910. PMID: 24880214, PMCID: PMC4113214, DOI: 10.1038/nn.3725.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell CountEatingExcitatory Postsynaptic PotentialsGlial Fibrillary Acidic ProteinHypothalamusImmunohistochemistryIn Situ HybridizationLeptinMaleMelanocortinsMiceMice, KnockoutMicroscopy, ElectronNerve NetNeuronsPrimary Cell CulturePro-OpiomelanocortinPulmonary Gas ExchangeReal-Time Polymerase Chain ReactionRNA, MessengerSignal Transduction
2009
A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure
Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G. A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure. Cell 2009, 138: 976-989. PMID: 19737523, PMCID: PMC2768582, DOI: 10.1016/j.cell.2009.06.051.Peer-Reviewed Original ResearchMeSH KeywordsAppetiteBone DensityBrain StemEnergy MetabolismHypothalamusLeptinReceptors, LeptinSerotoninSignal TransductionConceptsSerotonergic neuronsHypothalamic neuronsBone massEnergy expenditureVentromedial hypothalamic neuronsBone mass accrualSerotonin-dependent mechanismRegulation of appetiteEnergy expenditure phenotypesSpecific hypothalamic neuronsHtr2c receptorLeptin deficiencyArcuate neuronsLeptin inhibitionSerotonin synthesisLeptin receptorLeptin regulationLeptinNeuronsAppetiteReceptorsEnergy metabolismBrainBoneMolecular basis
2006
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ. Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding. Neuron 2006, 51: 801-810. PMID: 16982424, DOI: 10.1016/j.neuron.2006.08.023.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsDopamineEatingFeeding BehaviorGene ExpressionIn Situ Hybridization, FluorescenceIn Vitro TechniquesInfusions, IntravenousLeptinMesencephalonMiceMice, Inbred C57BLMotor ActivityNeuronsPhosphorylationRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, LeptinRNA InterferenceRNA, MessengerSignal TransductionSTAT3 Transcription FactorVentral Tegmental AreaConceptsVentral tegmental areaVTA dopamine neuronsDopamine neuronsFood intakePeripheral metabolic signalsNormal food intakeMidbrain dopamine neuronsLeptin receptor signalingLeptin hormoneTegmental areaLEPR expressionLeptin receptor functionLocomotor activityPalatable foodDirect administrationReceptor functionFiring rateReceptor signalingDirect actionNeuronsLEPR mRNAFunctional evidenceLeptinRNAi-mediated knockdownMetabolic signals