Prolyl Endopeptidase-Deficient Mice Have Reduced Synaptic Spine Density in the CA1 Region of the Hippocampus, Impaired LTP, and Spatial Learning and Memory
D'Agostino G, Kim JD, Liu ZW, Jeong JK, Suyama S, Calignano A, Gao XB, Schwartz M, Diano S. Prolyl Endopeptidase-Deficient Mice Have Reduced Synaptic Spine Density in the CA1 Region of the Hippocampus, Impaired LTP, and Spatial Learning and Memory. Cerebral Cortex 2012, 23: 2007-2014. PMID: 22767632, PMCID: PMC3841400, DOI: 10.1093/cercor/bhs199.Peer-Reviewed Original ResearchConceptsSynaptic spine densitySpine densityCA1 regionProlyl endopeptidaseHippocampal long-term potentiationLong-term potentiationHippocampal-mediated learningImpaired LTPWild-type controlsSpatial memory formationHippocampal plasticityCognitive impairmentPharmacological manipulationNeurodegenerative disordersSpatial learningMemory formationHippocampusPossible roleMicePhysiological functionsSerine proteasesBehavioral approachPotentiationDiseaseNeuropeptides