2021
Drp1 is required for AgRP neuronal activity and feeding
Jin S, Yoon NA, Liu ZW, Song JE, Horvath TL, Kim JD, Diano S. Drp1 is required for AgRP neuronal activity and feeding. ELife 2021, 10: e64351. PMID: 33689681, PMCID: PMC7946429, DOI: 10.7554/elife.64351.Peer-Reviewed Original ResearchConceptsAgRP neuronal activityFatty acid oxidationAgRP neuronsNeuronal activityAgRP neuronal functionHypothalamic AgRP neuronsBody weight regulationMitochondrial fatty acid utilizationWhole-body energy homeostasisHypothalamic orexigenic agoutiFatty acid utilizationAcid oxidationFat massCKO miceNeuronal activationPeptide-1Body weightNeuronal functionOrexigenic agoutiEnergy homeostasisMitochondrial fissionSignificant decreaseEnergy expenditureNeuronsAcid utilization
2016
UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness
Toda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S. UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell 2016, 164: 872-883. PMID: 26919426, PMCID: PMC4770556, DOI: 10.1016/j.cell.2016.02.010.Peer-Reviewed Original ResearchConceptsSystemic glucose homeostasisMitochondrial fissionCellular biological processesMitochondrial dynamicsGenetic manipulationGlucose homeostasisReactive oxygen speciesBiological processesMitochondrial adaptationsProtein 2Reduced reactive oxygen speciesOxygen speciesHomeostasisCritical roleMetabolic environmentGlucose-excited neuronsGlucose responsivenessFissionNeuronal circuitrySpeciesNeuronsRegulationVMH neuronsGlucose loadPool