2012
Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency
Christoffersson G, Zang G, Zhuang ZW, Vågesjö E, Simons M, Phillipson M, Welsh M. Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency. Angiogenesis 2012, 15: 469-480. PMID: 22562363, PMCID: PMC4059510, DOI: 10.1007/s10456-012-9275-z.Peer-Reviewed Original ResearchConceptsShb knockout mouseWild-type situationShb adapter proteinPatho-physiological responsesKnockout miceAdapter proteinAdherens junctionsShb deficiencyFunction of VEGFVE-cadherinVivo angiogenesisPhysiological conditionsAltered propertiesReceptor VEGFR-2Growth factorVascular endothelial growth factorVEGFR-2
2011
FGF-dependent regulation of VEGF receptor 2 expression in mice
Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL, Simons M. FGF-dependent regulation of VEGF receptor 2 expression in mice. Journal Of Clinical Investigation 2011, 121: 2668-2678. PMID: 21633168, PMCID: PMC3223828, DOI: 10.1172/jci44762.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedEndothelial CellsEnzyme ActivationFibroblast Growth FactorsHindlimbHumansIschemiaMiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Neovascularization, PhysiologicProto-Oncogene Proteins c-etsSignal TransductionVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth FactorsConceptsFGF-dependent regulationEts transcription factorsERK1/2-dependent mannerVEGF receptor-2 expressionActivation of ERK1/2Enhancer activationTranscriptional analysisTranscription factorsVEGFR2 expressionVascular morphogenesisFGF stimulationVEGF stimulationFGFVascular formationExpressionVascular integrityReceptor 2 expressionActivationMorphogenesisVEGFERK1/2Numerous studiesPathwayRegulationDownregulationChallenging the Surgical Rodent Hindlimb Ischemia Model with the Miniinterventional Technique
Zhuang ZW, Shi J, Rhodes JM, Tsapakos MJ, Simons M. Challenging the Surgical Rodent Hindlimb Ischemia Model with the Miniinterventional Technique. Journal Of Vascular And Interventional Radiology 2011, 22: 1437-1446. PMID: 21459613, PMCID: PMC3367666, DOI: 10.1016/j.jvir.2010.12.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Flow VelocityBone Marrow TransplantationChemokinesCytokinesDisease Models, AnimalEmbolization, TherapeuticFemoral ArteryHindlimbInflammation MediatorsIschemiaLaser-Doppler FlowmetryLigationMaleMuscle, SkeletalNeovascularization, PhysiologicRatsRats, Inbred LewRecovery of FunctionRegional Blood FlowTime FactorsConceptsMarrow mononuclear cellsLaser Doppler imagingRight femoral arterySurgical ligationFemoral arteryHindlimb ischemia modelSL groupInterventional embolizationIschemia modelBone marrow mononuclear cellsGranulocyte colony-stimulating factorPreserves tissue integrityColony-stimulating factorVivo microscopic imagesHindlimb ischemic modelChemokine assaysMassive scarringInflammatory infiltrationIL-18Lewis ratsNerve degenerationIL-13IL-6Mononuclear cellsIschemic model