Elevated follicular helper T Cells and expression of IL-21 in thyroid tissues are involved in the pathogenesis of Graves’ disease
Zhang J, Ren M, Zeng H, Guo Y, Zhuang Z, Feng Z, Yan H, Xu M, Liang W, Yang C, Cheng H, Ding H, Yan L. Elevated follicular helper T Cells and expression of IL-21 in thyroid tissues are involved in the pathogenesis of Graves’ disease. Immunologic Research 2015, 62: 163-174. PMID: 25894310, DOI: 10.1007/s12026-015-8647-z.Peer-Reviewed Original ResearchConceptsGD thyroid tissuesExpression of TfhFollicular helper T cellsThyroid follicular cellsPresence of TFHIL-21Helper T cellsThyroid tissueTSAb stimulationThyroid autoantibodiesIL-21RT cellsCAMP productionIL-21 stimulationPathogenesis of GDPathogenesis of GravesRelated factorsReal-time polymerase chain reactionNormal thyroid follicular cellsNormal thyroid tissueSerum levelsAutoimmune diseasesConfocal microscopyPolymerase chain reactionTfh