VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis
Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M. VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis. Developmental Cell 2010, 18: 713-724. PMID: 20434959, PMCID: PMC2875289, DOI: 10.1016/j.devcel.2010.02.016.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsArteriesCarrier ProteinsCell MembraneEndocytosisEndothelium, VascularGene SilencingMiceMice, KnockoutMorphogenesisMyosin Heavy ChainsNeuropeptidesPhosphorylationVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ZebrafishConceptsArterial morphogenesisSelective dephosphorylationPlasma membraneIntracellular traffickingKey growth factorsNull phenotypeMyosin VIMolecular eventsMorphogenesisVEGFR2 activationTraffickingIntracellular sitesKey eventsPTP1BNull miceKnockdownImpaired VEGFGrowth factorVEGFR2ActivationDephosphorylationEndosomesVEGFPhosphorylationSites