Challenging the Surgical Rodent Hindlimb Ischemia Model with the Miniinterventional Technique
Zhuang ZW, Shi J, Rhodes JM, Tsapakos MJ, Simons M. Challenging the Surgical Rodent Hindlimb Ischemia Model with the Miniinterventional Technique. Journal Of Vascular And Interventional Radiology 2011, 22: 1437-1446. PMID: 21459613, PMCID: PMC3367666, DOI: 10.1016/j.jvir.2010.12.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Flow VelocityBone Marrow TransplantationChemokinesCytokinesDisease Models, AnimalEmbolization, TherapeuticFemoral ArteryHindlimbInflammation MediatorsIschemiaLaser-Doppler FlowmetryLigationMaleMuscle, SkeletalNeovascularization, PhysiologicRatsRats, Inbred LewRecovery of FunctionRegional Blood FlowTime FactorsConceptsMarrow mononuclear cellsLaser Doppler imagingRight femoral arterySurgical ligationFemoral arteryHindlimb ischemia modelSL groupInterventional embolizationIschemia modelBone marrow mononuclear cellsGranulocyte colony-stimulating factorPreserves tissue integrityColony-stimulating factorVivo microscopic imagesHindlimb ischemic modelChemokine assaysMassive scarringInflammatory infiltrationIL-18Lewis ratsNerve degenerationIL-13IL-6Mononuclear cellsIschemic model