2013
Expanding Horizons: Ciliary Proteins Reach Beyond Cilia
Yuan S, Sun Z. Expanding Horizons: Ciliary Proteins Reach Beyond Cilia. Annual Review Of Genetics 2013, 47: 353-376. PMID: 24016188, PMCID: PMC5703194, DOI: 10.1146/annurev-genet-111212-133243.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, MultipleAnimalsBardet-Biedl SyndromeCell MovementCerebellar DiseasesCerebellumCiliaCiliary Motility DisordersDisease Models, AnimalDNA DamageDNA RepairEncephaloceleEye AbnormalitiesFlagellaHeterotaxy SyndromeHomeostasisHumansKidney Diseases, CysticMolecular Motor ProteinsNervous SystemPolycystic Kidney DiseasesPolycystic Kidney, Autosomal DominantPolycystic Kidney, Autosomal RecessiveRetinaRetinitis PigmentosaChapter Nine Dissecting the Functional Interplay Between the TOR Pathway and the Cilium in Zebrafish
Yuan S, Zhao L, Sun Z. Chapter Nine Dissecting the Functional Interplay Between the TOR Pathway and the Cilium in Zebrafish. Methods In Enzymology 2013, 525: 159-189. PMID: 23522470, DOI: 10.1016/b978-0-12-397944-5.00009-2.Peer-Reviewed Original ResearchConceptsTOR pathwayCilia length controlGreen alga ChlamydomonasKupffer's vesiclePatterning defectsCiliary precursorsNutrient cuesCiliopathic phenotypesVertebrate modelTranslational regulationAlga ChlamydomonasCilia morphologyFunctional interplayEmbryonic organsFluid flow generationZebrafishCellular growthCilia lengthMajor regulatorChlamydomonasRapamycin (mTOR) pathwayLength controlCiliary motilityFundamental processesMechanistic relationship
2012
TORC1-mediated protein synthesis regulates cilia size and function
Yuan S, Sun Z. TORC1-mediated protein synthesis regulates cilia size and function. Cell Cycle 2012, 11: 1750-1752. PMID: 22517434, PMCID: PMC3372384, DOI: 10.4161/cc.20312.Peer-Reviewed Original Research
2011
A cell‐based screen for inhibitors of flagella‐driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow
Engel BD, Ishikawa H, Feldman JL, Wilson CW, Chuang P, Snedecor J, Williams J, Sun Z, Marshall WF. A cell‐based screen for inhibitors of flagella‐driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow. Cytoskeleton 2011, 68: 188-203. PMID: 21360831, DOI: 10.1002/cm.20504.Peer-Reviewed Original ResearchConceptsRetrograde actin flowActin flowUnicellular green alga Chlamydomonas reinhardtiiGreen alga Chlamydomonas reinhardtiiFlagella-driven motilityDrosophila S2 cellsAlga Chlamydomonas reinhardtiiTraditional genetic methodsChemical biology toolkitCell-based screenHuman disease symptomsLength of ciliaCiliary assemblyFlagellar paralysisS2 cellsIntraflagellar transportGenetic toolsFlagellar shorteningChlamydomonas reinhardtiiMammalian cellsSensory organellesGenetic methodsCiliary lengthCiliary defectsNovel modulator
2010
Cilia in cell signaling and human disorders
Duldulao NA, Li J, Sun Z. Cilia in cell signaling and human disorders. Protein & Cell 2010, 1: 726-736. PMID: 21203914, PMCID: PMC4875200, DOI: 10.1007/s13238-010-0098-7.Peer-Reviewed Original ResearchConceptsRole of ciliaUnrelated human diseasesMulticellular organismsVestigial organelleCell signalingCellular organellesNormal organogenesisHuman disordersHuman diseasesCiliaKidney cystsOrganellesSensory roleNeural tube defectsCiliogenesisOrganogenesisDevelopmental disordersMotileOrganismsSignalingTube defectsRoleDefects