Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation
Yuan S, Li J, Diener DR, Choma MA, Rosenbaum JL, Sun Z. Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 2021-2026. PMID: 22308353, PMCID: PMC3277533, DOI: 10.1073/pnas.1112834109.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCiliaEvolution, MolecularGene Knockdown TechniquesGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansMovementOrgan SizeProtein BiosynthesisRheologyRibosomal Protein S6 KinasesSignal TransductionTranscription FactorsTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsZebrafishZebrafish ProteinsConceptsCilia lengthRibosomal protein S6 kinase 1Protein S6 kinase 1Protein synthesisLeft-right body asymmetryProtein synthesis regulationS6 kinase 1Vertebrate developmentTOR pathwayCilium sizeZebrafish developmentCilia assemblyTreatment of embryosDownstream substratesCilia morphologyEnvironmental cuesSynthesis regulationFluid flow generationKinase 1Cellular antennaHuman disordersCilia motilityUpstream inhibitorProper functionCiliary function