2001
Sedation, Risk, and Safety: Do We Really Have Data at Last?
Polaner D, Houck C, Rockoff M, Mancuso T, Finley G, Maxwell L, Cravero J, Kain Z, Bell C, Bosenberg A, Zwass M, Valley R, Agarwal R, Savarese A, Rice L, Coté C, Davidson P, Ferrari L, Davis P. Sedation, Risk, and Safety: Do We Really Have Data at Last? Pediatrics 2001, 108: 1006-1008. PMID: 11581458, DOI: 10.1542/peds.108.4.1006.Peer-Reviewed Original Research
2000
Attenuation of the Preoperative Stress Response with Midazolam
Kain Z, Sevarino F, Pincus S, Alexander G, Wang S, Ayoub C, Kosarussavadi B. Attenuation of the Preoperative Stress Response with Midazolam. Anesthesiology 2000, 93: 141-147. PMID: 10861157, DOI: 10.1097/00000542-200007000-00024.Peer-Reviewed Original ResearchConceptsPlacebo groupTreatment groupsPostoperative anxietyPreoperative sedativesPreoperative stress responsePlacebo-controlled trialFirst postoperative weekGreater reductionGlobal health indexAnalgesic consumptionIbuprofen usePlacebo injectionsPostoperative painClinical recoveryIntramuscular midazolamSurgery lengthPain recoveryPostoperative weekAnesthetic techniqueGeneral anesthesiaOutpatient surgeryPreoperative outcomesClinical significanceMidazolamSurgery
1999
Preoperative Anxiety and Intraoperative Anesthetic Requirements
Maranets I, Kain Z. Preoperative Anxiety and Intraoperative Anesthetic Requirements. Anesthesia & Analgesia 1999, 89: 1346. DOI: 10.1213/00000539-199912000-00003.Peer-Reviewed Original ResearchConceptsIntraoperative anesthetic requirementsMaintenance of anesthesiaAnesthetic requirementsPropofol dosesPreoperative anxietyBaseline anxietyHypnotic componentAnesthetic stateIntraoperative propofol requirementsLaparoscopic tubal ligationCross-sectional studyHigh baseline anxietyAnxiety levelsBispectral index monitorMore propofolAnesthetic regimenIndependent predictorsPropofol requirementsInitial doseTubal ligationLarge dosesPatientsState anxietyAnxious patientsAnesthesiaPreoperative anxiety and intraoperative anesthetic requirements.
Maranets I, Kain Z. Preoperative anxiety and intraoperative anesthetic requirements. Anesthesia & Analgesia 1999, 89: 1346-51. PMID: 10589606, DOI: 10.1097/00000539-199912000-00003.Peer-Reviewed Original ResearchConceptsIntraoperative anesthetic requirementsTrait anxietyMaintenance of anesthesiaAnesthetic requirementsAnxiety levelsLow trait anxietyPropofol doseHigh trait anxietyLaparoscopic tubal ligationIntraoperative propofol requirementsAnesthetic stateDoses of anestheticsCross-sectional studyTubal ligationInitial doseBaseline anxietyAnxious patientsHypnotic componentState anxietyLarger dosesAnxietyInduction doseBispectral index monitoringPatientsDose
1998
Parental Presence during Induction of Anesthesia versus Sedative Premedication
Kain Z, Mayes L, Wang S, Caramico L, Hofstadter M. Parental Presence during Induction of Anesthesia versus Sedative Premedication. Anesthesiology 1998, 89: 1147-1156. PMID: 9822003, DOI: 10.1097/00000542-199811000-00015.Peer-Reviewed Original ResearchConceptsInduction of anesthesiaMidazolam groupControl groupParental presenceOral midazolamEnd pointParental presence groupPrimary end pointSecondary end pointsParental anxiety scoresPerioperative periodPreoperative periodPreoperative anxietySedative premedicationAnesthesia maskAnesthesiaMidazolamOperating roomAnxiety scoresParent anxietyChildrenLess anxietyInterventionAnxietyInductionThe Sedative and Analgesic Sparing Effect of Music
Koch M, Kain Z, Ayoub C, Rosenbaum S. The Sedative and Analgesic Sparing Effect of Music. Anesthesiology 1998, 89: 300-306. PMID: 9710387, DOI: 10.1097/00000542-199808000-00005.Peer-Reviewed Original ResearchConceptsDuration of surgeryAnalgesic requirementsIntraoperative musicPatient-controlled intravenous opioid analgesiaAnalgesic sparing effectIntravenous opioid analgesiaIntravenous propofol sedationPostanesthesia care unitEffects of musicMusic groupDuration of stayPhase 2Phase 1Operating room noiseAlfentanil requirementsOpioid analgesiaAdverse eventsLess propofolSpinal anesthesiaAwake patientsCare unitAdverse outcomesPropofol sedationSparing effectUreteral calculi