A 5‐HT2C receptor promoter polymorphism (HTR2C − 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes
Pooley EC, Fairburn CG, Cooper Z, Sodhi MS, Cowen PJ, Harrison PJ. A 5‐HT2C receptor promoter polymorphism (HTR2C − 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 126B: 124-127. PMID: 15048662, DOI: 10.1002/ajmg.b.20143.Peer-Reviewed Original ResearchConceptsObese womenWeight lossPromoter polymorphismNon-obese womenHigh triglyceride levelsInfluences weight lossAnti-obesity drugsRT-PCR studiesObese groupT statusTriglyceride levelsRisk factorsAntipsychotic drugsObesity trialsFrontal cortexPharmacogenetic testingSerotonin 5C subjectsBody weightC alleleWeight gainObesityT subjectsWomenPsychological treatment