TrAp: a tree approach for fingerprinting subclonal tumor composition
Strino F, Parisi F, Micsinai M, Kluger Y. TrAp: a tree approach for fingerprinting subclonal tumor composition. Nucleic Acids Research 2013, 41: e165-e165. PMID: 23892400, PMCID: PMC3783191, DOI: 10.1093/nar/gkt641.Peer-Reviewed Original ResearchConceptsGenome-wide experimentsEvolutionary relationshipsMutational profileSequencing technologiesMixed cell populationsSilico analysisTumor samplesCell subpopulationsEvolutionary frameworkNumber of subpopulationsSingle cellsEvolutionary pathCell populationsCollective signalClonal compositionMetastatic potentialNumerous cellsTumor karyotypeComputational approachSubpopulationsCellsMixed subpopulationsAbundanceDistinct metastasesTumor composition