Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity
Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urbán G, Monory K, Marsicano G, Matteoli M, Canty A, Irving AJ, Katona I, Yanagawa Y, Rakic P, Lutz B, Mackie K, Harkany T. Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity. Science 2007, 316: 1212-1216. PMID: 17525344, DOI: 10.1126/science.1137406.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCannabinoid Receptor ModulatorsCell MovementCells, CulturedCerebral CortexEndocannabinoidsGamma-Aminobutyric AcidGrowth ConesIn Situ HybridizationInterneuronsMiceMice, Inbred C57BLMicroscopy, ConfocalRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Signal TransductionStem CellsSynapsesUltrasonographyXenopus laevisXenopus ProteinsConceptsAxonal growth conesGABAergic interneuronsEndocannabinoid signalingXenopus laevis spinal neuronsCortical GABAergic interneuronsCentral nervous system developmentGrowth conesAxon guidance cuesSpinal neuronsNervous system developmentCannabinoid receptorsLate gestationNeuronal connectivityRodent cortexInterneuronsEndocannabinoidsGuidance cuesTarget selectionSignalingGestationCortexSynaptogenesisNeuronsBrainReceptors