FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67 Promoter Region
Yamamoto Y, Kida H, Kagawa Y, Yasumoto Y, Miyazaki H, Islam A, Ogata M, Yanagawa Y, Mitsushima D, Fukunaga K, Owada Y. FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67 Promoter Region. Journal Of Neuroscience 2018, 38: 10411-10423. PMID: 30341178, PMCID: PMC6596254, DOI: 10.1523/jneurosci.1285-18.2018.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexHistone deacetylase 1KO miceCellular chaperonesFatty acid-binding proteinMethionine administrationTranscriptional repressor complexMouse anterior cingulate cortexGlutamic acid decarboxylase 67Promoter methylationEnzyme glutamic acid decarboxylase 67Emotional behaviorKO male miceGABAergic inhibitory interneuronsRepressor complexTranscriptional regulationSignal transductionAcid-binding proteinDNA methylationGene transcriptionMethyl-CpGIntracellular traffickingPromoter regionHuman psychiatric disordersPUFA homeostasis