Featured Publications
Mpox and Sexually Transmitted Infection Testing in the Outpatient Primary Care Setting—Why LGBTQ Health Is Global Health
Ilagan-Ying Y, Fisher A, Zimmerman A, Pellegrino A, Roberts S. Mpox and Sexually Transmitted Infection Testing in the Outpatient Primary Care Setting—Why LGBTQ Health Is Global Health. Journal Of General Internal Medicine 2023, 38: 1067-1071. PMID: 36633799, PMCID: PMC10039215, DOI: 10.1007/s11606-022-07988-2.Peer-Reviewed Original ResearchInpatient teaching with a clinical review game
Ilagan‐Ying Y, Windish DM, Wijesekera TP. Inpatient teaching with a clinical review game. The Clinical Teacher 2022, 19: e13522. PMID: 35989497, DOI: 10.1111/tct.13522.Peer-Reviewed Original ResearchConceptsReview gameTeaching pointsInpatient teachingCollaborative educational environmentSelf-directed learningPeer teachingPreclinical curriculumEducational environmentEducational experienceClinical educationEvidence-based practiceLearner evaluationPowerPoint templateCrowdsourced learningMedical studentsCollaborative cultureCurrent evidence-based practiceTeachingLearnersRotation evaluationsRelevant contentSocial distancing policiesLearningPandemic restrictionsPrimary literaturePancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites
Ilagan-Ying YC, Park EY, Lam R, Gupta S. Pancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites. Journal Of General Internal Medicine 2022, 37: 2082-2085. PMID: 35260958, PMCID: PMC9198176, DOI: 10.1007/s11606-022-07463-y.Peer-Reviewed Case Reports and Technical NotesIncreased Mortality in Patients Undergoing Inpatient Endoscopy During the Early COVID-19 Pandemic
Ilagan-Ying YC, Almeida MN, Kahler-Quesada A, Ying L, Hughes ML, Do A, Hung KW. Increased Mortality in Patients Undergoing Inpatient Endoscopy During the Early COVID-19 Pandemic. Digestive Diseases And Sciences 2022, 67: 5053-5062. PMID: 35182250, PMCID: PMC8857390, DOI: 10.1007/s10620-022-07414-x.Peer-Reviewed Original ResearchConceptsInpatient endoscopyCare centerEndoscopic proceduresIntensive care unit admissionAcademic tertiary care centerCare unit admissionProportion of patientsTertiary care centerCoronavirus disease 2019 (COVID-19) pandemicHigher mortality riskDisease 2019 pandemicEarly COVID-19 pandemicICU admissionUnit admissionPatient demographicsUrgent indicationsBlood transfusionFirst waveHigher proportionPatient reluctanceMale genderUrgent proceduresProcedural characteristicsHospital careMost healthcare systemsLow real-world eligibility rates for nonalcoholic steatohepatitis patients for phase 3 clinical trial criteria application in a large academic health system.
Ilagan-Ying YC, Xu J, Lim JK, Do A. Low real-world eligibility rates for nonalcoholic steatohepatitis patients for phase 3 clinical trial criteria application in a large academic health system. European Journal Of Gastroenterology & Hepatology 2020, 33: 424-429. PMID: 32433419, PMCID: PMC7674230, DOI: 10.1097/meg.0000000000001758.Peer-Reviewed Original ResearchConceptsUniversity-based cohortNonalcoholic steatohepatitisEnrollment criteriaLiver biopsyClinical trialsHealth system's electronic medical recordDiagnosis of NASHSystem's electronic medical recordGlobal phase 3Obeticholic acid treatmentPivotal phase 3Trial enrollment criteriaLarge academic health systemCommon liver diseaseNonalcoholic steatohepatitis patientsMultiple logistic regressionReal-world populationAcademic health systemPhase 3Electronic medical recordsMedical comorbiditiesReal-world generalizabilitySteatohepatitis patientsLaboratory abnormalitiesNASH patientsOpen management of complex infrarenal aortic occlusive disease.
Ilagan-Ying Y, Tonnessen B. Open management of complex infrarenal aortic occlusive disease. The Journal Of Cardiovascular Surgery 2023, 64: 361-371. PMID: 37162241, DOI: 10.23736/s0021-9509.23.12680-2.Peer-Reviewed Original ResearchConceptsAortic occlusive diseaseOcclusive diseaseAortic surgeryComplex aortoiliac occlusive diseaseInfrarenal aortic occlusive diseaseChronic limb threatening ischemiaAortoiliac occlusive diseaseLimb threatening ischemiaOpen aortic surgeryAdvanced endovascular techniquesSenior author's experienceAortic bypassAortoiliac revascularizationMultilevel diseaseAortic reconstructionIliofemoral bypassEndovascular techniquesOperative approachPertinent articlesDiseaseOpen managementSurgeryBypassComprehensive literature reviewLiterature review
2024
Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis
Ilagan-Ying Y, Gordon K, Tate J, Lim J, Torgersen J, Re V, Justice A, Taddei T. Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis. JAMA Network Open 2024, 7: e2443608. PMID: 39504020, PMCID: PMC11541635, DOI: 10.1001/jamanetworkopen.2024.43608.Peer-Reviewed Original ResearchConceptsClassification of DiseasesBody mass indexRisk scoreNinth Revision and International Statistical Classification of DiseasesMass indexAlcohol useInternational Statistical Classification of DiseasesStatistical Classification of DiseasesElectronic health recordsNon-Hispanic blacksInternational Classification of DiseasesNon-Hispanic whitesClinical Modification diagnosisHepatocellular carcinoma risk scoreRisk of hepatocellular carcinomaCox proportional hazards regression modelsValidation sampleHigh-risk individualsProportional hazards regression modelsHCC risk factorsFIB-4Multivariate risk scoreHepatocellular carcinomaHazards regression modelsViral hepatitisTeaching Sideways: Implementing a Peer-Led Medical Student Orientation Bootcamp and Survival Guide for Internal Medicine Clerkship
Ramakrishnan D, Ilagan-Ying Y, Bollinger B, Dunne D. Teaching Sideways: Implementing a Peer-Led Medical Student Orientation Bootcamp and Survival Guide for Internal Medicine Clerkship. Southern Medical Journal 2024, 117: 1-6. PMID: 38151243, DOI: 10.14423/smj.0000000000001638.Peer-Reviewed Original ResearchConceptsMedical schoolsStudent confidenceStudent expectationsClerkship yearMedical studentsPostclerkship surveyStudent confidence ratingsPercentage of studentsInternal medicine clerkshipSurvival GuideStudent cohortsStudent questionsClerkship studentsMedicine clerkshipClerkship evaluationsClerkshipStudentsBootcampMentorship approachSchoolsPreparation materialsCore topicsLikert scaleIdentification of waysIM rotations
2023
Addressing Cognitive Biases in Interpreting an Elevated Lactate in a Patient with Type 1 Diabetes and Thiamine Deficiency
Chehayeb R, Ilagan-Ying Y, Sankey C. Addressing Cognitive Biases in Interpreting an Elevated Lactate in a Patient with Type 1 Diabetes and Thiamine Deficiency. Journal Of General Internal Medicine 2023, 38: 1547-1551. PMID: 36814053, PMCID: PMC9946700, DOI: 10.1007/s11606-023-08091-w.Peer-Reviewed Original ResearchConceptsThiamine deficiencyExtensive infectious workupLactic acid elevationElevated lactate levelsType 1 diabetesInfectious workupDiabetic ketoacidosisThiamine administrationAppropriate patientsClinical patternElevated lactateLactate levelsPatient careYoung womenPatientsCOVID-19 pandemicCareDeficiencyElevationKetoacidosisDiabetesEtiologyWorkupCliniciansAdministration
2022
Alternative HCC prognostic biomarkers and use of artificial intelligence in the management of HCC
Jaffe A, Taddei T, Giannini E, Ilagan‐Ying Y, Colombo M, Strazzabosco M. Alternative HCC prognostic biomarkers and use of artificial intelligence in the management of HCC. Liver International 2022, 43: 258-259. PMID: 36426717, DOI: 10.1111/liv.15482.Peer-Reviewed Original ResearchHolistic management of hepatocellular carcinoma: The hepatologist's comprehensive playbook
Jaffe A, Taddei TH, Giannini EG, Ilagan‐Ying Y, Colombo M, Strazzabosco M. Holistic management of hepatocellular carcinoma: The hepatologist's comprehensive playbook. Liver International 2022, 42: 2607-2619. PMID: 36161463, PMCID: PMC10878125, DOI: 10.1111/liv.15432.Peer-Reviewed Original ResearchConceptsLiver diseaseHepatocellular carcinomaLiver functionRisk factorsRelevant prognostic roleChronic hepatitis BResidual liver functionChronic liver diseaseManagement of patientsCare of patientsCommon risk factorsAppropriate surveillance strategiesSuccessful cancer treatmentC infectionCommon complicationHepatitis BMetabolic syndromePrognostic roleSignificant morbidityLongitudinal careCurrent careCancer recurrenceHCC managementLiver cancerHCC treatment
2020
Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient
Lier AJ, Virmani S, Ilagan‐Ying Y, Leelatian N, Darbinyan A, Malinis M. Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient. Transplant Infectious Disease 2020, 23: e13491. PMID: 33040432, DOI: 10.1111/tid.13491.Peer-Reviewed Case Reports and Technical NotesConceptsUnilateral leg painKidney transplant recipientsTransplant recipientsCryptococcal infectionLeg painFemale kidney transplant recipientSolid organ transplant recipientsPrevious graft failureHypoxemic respiratory failureMulti-organ failureOrgan transplant recipientsDisseminated cryptococcal infectionPneumocystis jirovecii pneumoniaShortness of breathLiposomal amphotericin BGround-glass opacitiesCryptococcal myositisDisseminated cryptococcosisCryptococcal meningitisRespiratory failureAggressive managementGraft failureJirovecii pneumoniaOverall survivalSeptic shockDrug development of nonalcoholic fatty liver disease: challenges in research, regulatory pathways, and study endpoints
Do A, Ilagan-Ying YC, Mehal WZ, Lim JK. Drug development of nonalcoholic fatty liver disease: challenges in research, regulatory pathways, and study endpoints. Expert Opinion On Drug Discovery 2020, 16: 125-134. PMID: 33086894, DOI: 10.1080/17460441.2020.1811674.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseNonalcoholic steatohepatitisLiver diseaseHealthcare resource burdenNovel trial designsClinical trial researchSignificant healthcareCase definitionClinical trialsEfficacious treatmentNew therapiesEndpoint definitionsTrial designTreatment targetsMetabolic diseasesTrial researchClinical researchDrug development processQuality data reportingDrug approvalDiseaseResource burdenRegulatory pathwaysDrug development
2014
Altered Genome-Wide Methylation in Endometriosis
Naqvi H, Ilagan Y, Krikun G, Taylor HS. Altered Genome-Wide Methylation in Endometriosis. Reproductive Sciences 2014, 21: 1237-1243. PMID: 24784717, PMCID: PMC5933183, DOI: 10.1177/1933719114532841.Peer-Reviewed Original ResearchConceptsGene expressionBone morphogenetic protein receptorGenome-wide methylationDual specificity phosphatase 22Morphogenetic protein receptorTumor protein 73Genome-wide methylation arrayAberrant DNA methylationInhibitor of DNADNA methylationCandidate genesBinding protein 7Member 21Methylation arraysProtein receptorsQuantitative real-time polymerase chain reactionGenesImmunoglobulin SuperfamilyAberrant methylationMethylation statusProtein 7MethylationCell proliferationAbnormal regulationReceptor 1B