Featured Publications
Low real-world eligibility rates for nonalcoholic steatohepatitis patients for phase 3 clinical trial criteria application in a large academic health system.
Ilagan-Ying YC, Xu J, Lim JK, Do A. Low real-world eligibility rates for nonalcoholic steatohepatitis patients for phase 3 clinical trial criteria application in a large academic health system. European Journal Of Gastroenterology & Hepatology 2020, 33: 424-429. PMID: 32433419, PMCID: PMC7674230, DOI: 10.1097/meg.0000000000001758.Peer-Reviewed Original ResearchConceptsUniversity-based cohortNonalcoholic steatohepatitisEnrollment criteriaLiver biopsyClinical trialsHealth system's electronic medical recordDiagnosis of NASHSystem's electronic medical recordGlobal phase 3Obeticholic acid treatmentPivotal phase 3Trial enrollment criteriaLarge academic health systemCommon liver diseaseNonalcoholic steatohepatitis patientsMultiple logistic regressionReal-world populationAcademic health systemPhase 3Electronic medical recordsMedical comorbiditiesReal-world generalizabilitySteatohepatitis patientsLaboratory abnormalitiesNASH patients
2024
Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis
Ilagan-Ying Y, Gordon K, Tate J, Lim J, Torgersen J, Re V, Justice A, Taddei T. Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis. JAMA Network Open 2024, 7: e2443608. PMID: 39504020, PMCID: PMC11541635, DOI: 10.1001/jamanetworkopen.2024.43608.Peer-Reviewed Original ResearchConceptsClassification of DiseasesBody mass indexRisk scoreNinth Revision and International Statistical Classification of DiseasesMass indexAlcohol useInternational Statistical Classification of DiseasesStatistical Classification of DiseasesElectronic health recordsNon-Hispanic blacksInternational Classification of DiseasesNon-Hispanic whitesClinical Modification diagnosisHepatocellular carcinoma risk scoreRisk of hepatocellular carcinomaCox proportional hazards regression modelsValidation sampleHigh-risk individualsProportional hazards regression modelsHCC risk factorsFIB-4Multivariate risk scoreHepatocellular carcinomaHazards regression modelsViral hepatitis
2023
Addressing Cognitive Biases in Interpreting an Elevated Lactate in a Patient with Type 1 Diabetes and Thiamine Deficiency
Chehayeb R, Ilagan-Ying Y, Sankey C. Addressing Cognitive Biases in Interpreting an Elevated Lactate in a Patient with Type 1 Diabetes and Thiamine Deficiency. Journal Of General Internal Medicine 2023, 38: 1547-1551. PMID: 36814053, PMCID: PMC9946700, DOI: 10.1007/s11606-023-08091-w.Peer-Reviewed Original ResearchConceptsThiamine deficiencyExtensive infectious workupLactic acid elevationElevated lactate levelsType 1 diabetesInfectious workupDiabetic ketoacidosisThiamine administrationAppropriate patientsClinical patternElevated lactateLactate levelsPatient careYoung womenPatientsCOVID-19 pandemicCareDeficiencyElevationKetoacidosisDiabetesEtiologyWorkupCliniciansAdministration
2020
Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient
Lier AJ, Virmani S, Ilagan‐Ying Y, Leelatian N, Darbinyan A, Malinis M. Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient. Transplant Infectious Disease 2020, 23: e13491. PMID: 33040432, DOI: 10.1111/tid.13491.Peer-Reviewed Case Reports and Technical NotesConceptsUnilateral leg painKidney transplant recipientsTransplant recipientsCryptococcal infectionLeg painFemale kidney transplant recipientSolid organ transplant recipientsPrevious graft failureHypoxemic respiratory failureMulti-organ failureOrgan transplant recipientsDisseminated cryptococcal infectionPneumocystis jirovecii pneumoniaShortness of breathLiposomal amphotericin BGround-glass opacitiesCryptococcal myositisDisseminated cryptococcosisCryptococcal meningitisRespiratory failureAggressive managementGraft failureJirovecii pneumoniaOverall survivalSeptic shock
2017
Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression
Ilagan Y, Mamillapalli R, Goetz L, Kayani J, Taylor HS. Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression. Reproductive Toxicology 2017, 71: 84-94. PMID: 28476547, DOI: 10.1016/j.reprotox.2017.05.001.Peer-Reviewed Original ResearchConceptsBPA exposureGene expressionAdult gene expressionFetal BPA exposureBisphenol A (BPA) exposureMetabolic gene expressionEstrogen receptor alphaExpression of genesBeta gene expressionEstrogenic stateEstrogen treatmentPregnant miceMetabolic disordersE2 stimulationReceptor alphaFetal developmentLipid metabolismDay 9Developmental programmingSexual dimorphismFemale offspringLiverObesityGenesAdult responses
2016
Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk
Fischer C, Mamillapalli R, Goetz T, Jorgenson E, Ilagan Y, Taylor HS. Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Discover Oncology 2016, 7: 241-251. PMID: 26911702, PMCID: PMC10726733, DOI: 10.1007/s12672-016-0254-5.Peer-Reviewed Original ResearchConceptsBPA exposureBreast cancerAdaptive immunityMammary glandPosterior mammary glandsTh1 T cellsAberrant immune responseAbnormal mammary gland developmentHuman breast cancerPossible environmental etiologyInterleukin-1 gene familyMammary gland developmentMouse mammary tissueCytolytic CD8Osmotic minipumpsCD1 miceT cellsImmune responseGene familyExpression of membersCXC familyMammary tissueDevelopmental programmingUteroWestern blot
2014
Altered Genome-Wide Methylation in Endometriosis
Naqvi H, Ilagan Y, Krikun G, Taylor HS. Altered Genome-Wide Methylation in Endometriosis. Reproductive Sciences 2014, 21: 1237-1243. PMID: 24784717, PMCID: PMC5933183, DOI: 10.1177/1933719114532841.Peer-Reviewed Original ResearchConceptsGene expressionBone morphogenetic protein receptorGenome-wide methylationDual specificity phosphatase 22Morphogenetic protein receptorTumor protein 73Genome-wide methylation arrayAberrant DNA methylationInhibitor of DNADNA methylationCandidate genesBinding protein 7Member 21Methylation arraysProtein receptorsQuantitative real-time polymerase chain reactionGenesImmunoglobulin SuperfamilyAberrant methylationMethylation statusProtein 7MethylationCell proliferationAbnormal regulationReceptor 1B