2004
An Evolutionary Perspective on Single-Nucleotide Polymorphism Screening in Molecular Cancer Epidemiology
Zhu Y, Spitz MR, Amos CI, Lin J, Schabath MB, Wu X. An Evolutionary Perspective on Single-Nucleotide Polymorphism Screening in Molecular Cancer Epidemiology. Cancer Research 2004, 64: 2251-2257. PMID: 15026370, DOI: 10.1158/0008-5472.can-03-2800.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsAmino acidsConservation levelDifferent cancer-related genesHuman DNA repair genesTolerance indexMolecular evolutionary approachEntire human genomeNonsynonymous single nucleotide polymorphismsSingle nucleotide polymorphism (SNP) screeningTarget single nucleotide polymorphismsDNA repair genesAmino acid changesEvolutionary conservationHuman genomeCancer-related genesMolecular epidemiological studiesSelective pressureMolecular cancer epidemiologyDifferent speciesPhenotypic functionsAcid changesRepair genesEvolutionary perspectivePolymorphism screening
2003
Telomere Dysfunction: A Potential Cancer Predisposition Factor
Wu X, Amos C, Zhu Y, Zhao H, Grossman B, Shay J, Luo S, Hong W, Spitz M. Telomere Dysfunction: A Potential Cancer Predisposition Factor. Journal Of The National Cancer Institute 2003, 95: 1211-1218. PMID: 12928346, DOI: 10.1093/jnci/djg011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlotting, SouthernCarcinoma, Renal CellCase-Control StudiesDNA DamageDNA RepairDNA, NeoplasmFemaleFlow CytometryGenetic Predisposition to DiseaseHead and Neck NeoplasmsHumansIn Situ Hybridization, FluorescenceKidney NeoplasmsLung NeoplasmsLymphocytesMaleMiddle AgedNeoplasmsOdds RatioRisk AssessmentRisk FactorsSmokingTelomereUrinary Bladder NeoplasmsConceptsControl subjectsTelomere lengthNeck cancerOdds ratioCancer riskShort telomeresOngoing case-control studyPercent of patientsRenal cell cancerCase-control studyPeripheral blood lymphocytesLongest quartileCase patientsCell cancerSmoking statusDisease characteristicsBladder cancerBlood lymphocytesStratified analysisGenetic instabilityHuman bladderRenal cellsStudy participantsCancerPredisposition factors
2002
Genetic instability of specific chromosomes associated with a family history of cancer
Zhu Y, Spitz M, Hsu T, Wu X. Genetic instability of specific chromosomes associated with a family history of cancer. Cancer Genetics 2002, 136: 73-77. PMID: 12165456, DOI: 10.1016/s0165-4608(02)00513-7.Peer-Reviewed Original Research