microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis
Hoffman AE, Zheng T, Yi C, Leaderer D, Weidhaas J, Slack F, Zhang Y, Paranjape T, Zhu Y. microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis. Cancer Research 2009, 69: 5970-5977. PMID: 19567675, PMCID: PMC2716085, DOI: 10.1158/0008-5472.can-09-0236.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBase SequenceBreast NeoplasmsCell CycleCell Line, TumorCpG IslandsDNA MethylationEpigenesis, GeneticGene Expression ProfilingGene Regulatory NetworksGenetic Predisposition to DiseaseHumansMicroRNAsMiddle AgedModels, BiologicalMolecular Sequence DataOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideRisk FactorsTransfectionConceptsMiR-196a-2Cancer-relevant networkWhole-genome expression microarraysEpigenetic association studiesPathway-based analysisGenetic variantsCpG island upstreamCancer-related biological pathwaysCell cycle responseMiRNA genesFunctional genetic variantsMiRNA precursorsCommon sequence variantsTranscriptional regulatorsGenetic association analysisMutant precursorMutagenesis analysisTarget genesMature regionBreast cancer riskExpression microarraysFunctional analysisTumor suppressorBiological pathwaysAssociation studiesCancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis
Yi CH, Zheng T, Leaderer D, Hoffman A, Zhu Y. Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis. Cancer Letters 2009, 284: 149-156. PMID: 19457610, PMCID: PMC3182267, DOI: 10.1016/j.canlet.2009.04.017.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBasic Helix-Loop-Helix Transcription FactorsBreast NeoplasmsCell Line, TumorCell Transformation, NeoplasticChromatin ImmunoprecipitationCircadian RhythmFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksGenome-Wide Association StudyHumansNeoplasm ProteinsNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisRNA InterferenceRNA, Small InterferingTranscription, GeneticConceptsDirect transcriptional targetTranscriptional targetsCircadian genesGenome-wide mapping approachChip analysisGenome-wide ChIPCancer-related gene expressionCore circadian genesRelevant biological pathwaysTranscriptional profilesGene expressionReal-time PCR assaysBiological processesCell cycleBiological pathwaysNPAS2Biological involvementGenesHuman cancersMCF-7 cellsCancer developmentTumorigenesisPCR assaysCircadian rhythmTargetClock-Cancer Connection in Non–Hodgkin's Lymphoma: A Genetic Association Study and Pathway Analysis of the Circadian Gene Cryptochrome 2
Hoffman AE, Zheng T, Stevens RG, Ba Y, Zhang Y, Leaderer D, Yi C, Holford TR, Zhu Y. Clock-Cancer Connection in Non–Hodgkin's Lymphoma: A Genetic Association Study and Pathway Analysis of the Circadian Gene Cryptochrome 2. Cancer Research 2009, 69: 3605-3613. PMID: 19318546, PMCID: PMC3175639, DOI: 10.1158/0008-5472.can-08-4572.Peer-Reviewed Original ResearchConceptsCryptochrome 2Single nucleotide polymorphismsCircadian genesWhole-genome expression microarraysPathway-based analysisCore circadian genesCancer-related biological pathwaysCRY2 knockdownTranscriptional repressorGenetic association analysisGenetic association studiesExpression microarraysFunctional analysisPathway analysisAssociation studiesBiological pathwaysAssociation analysisGenesNucleotide polymorphismsGenetic associationCircadian biomarkersDNA samplesFunctional effectsImportant roleRepressor