microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis
Hoffman AE, Zheng T, Yi C, Leaderer D, Weidhaas J, Slack F, Zhang Y, Paranjape T, Zhu Y. microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis. Cancer Research 2009, 69: 5970-5977. PMID: 19567675, PMCID: PMC2716085, DOI: 10.1158/0008-5472.can-09-0236.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBase SequenceBreast NeoplasmsCell CycleCell Line, TumorCpG IslandsDNA MethylationEpigenesis, GeneticGene Expression ProfilingGene Regulatory NetworksGenetic Predisposition to DiseaseHumansMicroRNAsMiddle AgedModels, BiologicalMolecular Sequence DataOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideRisk FactorsTransfectionConceptsMiR-196a-2Cancer-relevant networkWhole-genome expression microarraysEpigenetic association studiesPathway-based analysisGenetic variantsCpG island upstreamCancer-related biological pathwaysCell cycle responseMiRNA genesFunctional genetic variantsMiRNA precursorsCommon sequence variantsTranscriptional regulatorsGenetic association analysisMutant precursorMutagenesis analysisTarget genesMature regionBreast cancer riskExpression microarraysFunctional analysisTumor suppressorBiological pathwaysAssociation studiesClock-Cancer Connection in Non–Hodgkin's Lymphoma: A Genetic Association Study and Pathway Analysis of the Circadian Gene Cryptochrome 2
Hoffman AE, Zheng T, Stevens RG, Ba Y, Zhang Y, Leaderer D, Yi C, Holford TR, Zhu Y. Clock-Cancer Connection in Non–Hodgkin's Lymphoma: A Genetic Association Study and Pathway Analysis of the Circadian Gene Cryptochrome 2. Cancer Research 2009, 69: 3605-3613. PMID: 19318546, PMCID: PMC3175639, DOI: 10.1158/0008-5472.can-08-4572.Peer-Reviewed Original ResearchConceptsCryptochrome 2Single nucleotide polymorphismsCircadian genesWhole-genome expression microarraysPathway-based analysisCore circadian genesCancer-related biological pathwaysCRY2 knockdownTranscriptional repressorGenetic association analysisGenetic association studiesExpression microarraysFunctional analysisPathway analysisAssociation studiesBiological pathwaysAssociation analysisGenesNucleotide polymorphismsGenetic associationCircadian biomarkersDNA samplesFunctional effectsImportant roleRepressor