2024
Clinical characteristics and influencing factors of severe fever with thrombocytopenia syndrome complicated by viral myocarditis: a retrospective study
Du Q, Yu J, Chen Q, Chen X, Jiang Q, Deng L, Li A, Xiong Y. Clinical characteristics and influencing factors of severe fever with thrombocytopenia syndrome complicated by viral myocarditis: a retrospective study. BMC Infectious Diseases 2024, 24: 240. PMID: 38389047, PMCID: PMC10885462, DOI: 10.1186/s12879-024-09096-4.Peer-Reviewed Original ResearchConceptsNT-proBNPConsciousness disorderClinical characteristicsViral myocarditisMultivariate analysisThrombocytopenia syndromeElevated platelet countElevated NT-proBNPIndependent risk factorRate of hypotensionSevere feverValues of LDHElevated LDHAbdominal painCardiac ultrasonographyMethodsRetrospective analysisPlatelet countD-dimerRetrospective studyLaboratory findingsClinical manifestationsAtrial fibrillationAbnormal electrocardiogramClinical dataRisk factors
2014
Kill HIV by Starvation–Mechanism of Allosteric Activation of SAMHD1
Ji X, Wu Y, Yan J, Mehrens J, DeLucia M, Hao C, Gronenborn A, Skowronski J, Anh J, Xiong Y. Kill HIV by Starvation–Mechanism of Allosteric Activation of SAMHD1. Acta Crystallographica Section A: Foundations And Advances 2014, 70: c121-c121. DOI: 10.1107/s2053273314098787.Peer-Reviewed Original ResearchCellular dNTP poolsCellular dNTP levelsDNTP poolsDNTP levelsDeoxyribonucleoside triphosphate triphosphohydrolaseActive tetrameric formMammalian cellsAllosteric activationSAMHD1 functionAllosteric mechanismMajor regulatorAllosteric siteInactive dimerAllosteric bindingTetrameric formAicardi-Goutières syndromeTetrameric complexMechanistic understandingCongenital viral infectionViral reverse transcriptionMonomers/dimersSAMHD1Reverse transcriptionHIV restrictionClinical manifestations