Adjusting for Background Mutation Frequency Biases Improves the Identification of Cancer Driver Genes
Evans P, Avey S, Kong Y, Krauthammer M. Adjusting for Background Mutation Frequency Biases Improves the Identification of Cancer Driver Genes. IEEE Transactions On NanoBioscience 2013, 12: 150-157. PMID: 23694700, PMCID: PMC3989533, DOI: 10.1109/tnb.2013.2263391.Peer-Reviewed Original ResearchConceptsMore non-synonymous mutationsMutation frequencyTumor sequencing projectsGene-specific mannerCancer driver genesNon-synonymous mutationsSynonymous mutation ratioMutation biasSequencing projectsBackground mutation frequencyGene expressionDriver genesGenesTumor developmentMutation burdenMutation ratioHigher non-synonymous mutation burdenMutationsMutation countsExpressionBackground frequencyFrequency biasesIdentification