2016
Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome
Kim Y, Lee HM, Xiong Y, Sciaky N, Hulbert SW, Cao X, Everitt JI, Jin J, Roth BL, Jiang YH. Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome. Nature Medicine 2016, 23: 213-222. PMID: 28024084, PMCID: PMC5589073, DOI: 10.1038/nm.4257.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineDisease Models, AnimalEnzyme InhibitorsEpigenesis, GeneticFemaleFibroblastsGene ExpressionGenomic ImprintingHistone CodeHistone-Lysine N-MethyltransferaseHumansImmunohistochemistryMaleMethylationMicePrader-Willi SyndromeQuinazolinesReverse Transcriptase Polymerase Chain ReactionRNA, Small NucleolarSnRNP Core ProteinsSurvival RateUbiquitin-Protein Ligases
2015
Adult Surgical Experience With Loeys-Dietz Syndrome
Williams JA, Hanna JM, Shah AA, Andersen ND, McDonald MT, Jiang YH, Wechsler SB, Zomorodi A, McCann RL, Hughes GC. Adult Surgical Experience With Loeys-Dietz Syndrome. The Annals Of Thoracic Surgery 2015, 99: 1275-1281. PMID: 25678502, DOI: 10.1016/j.athoracsur.2014.11.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAortic Aneurysm, ThoracicAortic DissectionCardiac Surgical ProceduresCohort StudiesFemaleHumansLoeys-Dietz SyndromeMaleMiddle AgedPostoperative ComplicationsPrognosisReoperationRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival RateTreatment OutcomeVascular Surgical ProceduresYoung AdultConceptsLoeys-Dietz syndromeAortic pathologySurgical experienceAggressive treatment strategiesSingle referral institutionAortic root replacementVascular surgical interventionTotal aortic replacementLate deathsAcute typeAortic replacementInfectious complicationsAdult patientsLDS patientsRoot replacementImproved survivalSurgical treatmentReferral institutionVascular catastrophesSurgical interventionCerebrovascular pathologySpecific phenotypic featuresClinical criteriaNeurosurgical interventionTreatment strategies