E6AP promotes the degradation of the PML tumor suppressor
Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang Y, Muller S, Scheffner M, Haupt S, Haupt Y. E6AP promotes the degradation of the PML tumor suppressor. Cell Death & Differentiation 2009, 16: 1156-1166. PMID: 19325566, DOI: 10.1038/cdd.2009.31.Peer-Reviewed Original ResearchConceptsPML-NBsNuclear bodiesTumor suppressorPromyelocytic leukemia (PML) tumor suppressorE3 ligase E6APPML tumor suppressorPML nuclear bodiesPML protein expressionUbiquitination assaysCertain human cancersStress signalsPML proteinImportant regulatorPML stabilityDNA damageE6APCell typesHuman cancersProtein expressionActive formNull micePhysiological levelsSuppressorGrowth inhibitionPML