The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling
Mansour M, Haupt S, Chan AL, Godde N, Rizzitelli A, Loi S, Caramia F, Deb S, Takano EA, Bishton M, Johnstone C, Monahan B, Levav-Cohen Y, Jiang YH, Yap AS, Fox S, Bernard O, Anderson R, Haupt Y. The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling. Cancer Research 2016, 76: 4236-4248. PMID: 27231202, DOI: 10.1158/0008-5472.can-15-1553.Peer-Reviewed Original ResearchConceptsBreast cancer patientsPoor prognosisCancer patientsBreast cancerBreast cancer-related deathsSuppresses breast cancer metastasisMetastatic breast cancerCancer-related deathBreast cancer metastasisBasal breast cancerBreast cancer invasivenessSteroid hormone receptorsMetastatic diseaseCurrent therapiesSecondary tumorsTherapeutic approachesTumor cell migrationCancer metastasisPatientsCancer invasivenessHormone receptorsMetastasisMajor causeHigh expressionE3 ubiquitin protein ligase