2009
E6AP promotes the degradation of the PML tumor suppressor
Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang Y, Muller S, Scheffner M, Haupt S, Haupt Y. E6AP promotes the degradation of the PML tumor suppressor. Cell Death & Differentiation 2009, 16: 1156-1166. PMID: 19325566, DOI: 10.1038/cdd.2009.31.Peer-Reviewed Original ResearchConceptsPML-NBsNuclear bodiesTumor suppressorPromyelocytic leukemia (PML) tumor suppressorE3 ligase E6APPML tumor suppressorPML nuclear bodiesPML protein expressionUbiquitination assaysCertain human cancersStress signalsPML proteinImportant regulatorPML stabilityDNA damageE6APCell typesHuman cancersProtein expressionActive formNull micePhysiological levelsSuppressorGrowth inhibitionPML
2002
Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction
Smith CL, DeVera DG, Lamb DJ, Nawaz Z, Jiang YH, Beaudet AL, O’Malley B. Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction. Molecular And Cellular Biology 2002, 22: 525-535. PMID: 11756548, PMCID: PMC139730, DOI: 10.1128/mcb.22.2.525-535.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug ResistanceFemaleFertilityGene ExpressionGrowthHistone AcetyltransferasesLigasesMaleMammary Glands, AnimalMiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Coactivator 1Nuclear Receptor Coactivator 3PregnancyProstateReceptors, SteroidReproductionSteroidsTrans-ActivatorsTranscription FactorsUbiquitin-Protein LigasesConceptsSteroid hormone actionWild-type controlsHormone actionProstate gland growthFemale knockout miceSteroid hormone resistanceE6-APSex steroid actionSteroid receptor coactivatorVirgin mammary glandMammary gland developmentReceptor-dependent gene expressionFemale miceUterine growthHormone resistanceSteroid actionKnockout miceNull miceGland growthType 1Genetic ablationMammary glandReceptor coactivatorMiceGland development