BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, Xiang J, Yuan X, Sun B, Sisodia SS, Jiang YH, Cao X, Jing N, Lin A. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. IScience 2021, 24: 102942. PMID: 34430820, PMCID: PMC8369003, DOI: 10.1016/j.isci.2021.102942.Peer-Reviewed Original ResearchNeuronal apoptosisAlzheimer's diseaseMicroglial phagocytosisMicroglial NLRP3 inflammasome activationDisease pathologyCommon progressive neurodegenerative diseaseProgressive neurodegenerative diseaseAlzheimer's disease pathologyNLRP3 inflammasome activationPotential therapeutic targetNeuroinflammatory microgliaAD miceAβ clearanceAD pathologyBad pro-apoptotic activityAD patientsInflammasome activationTherapeutic targetMemory deficitsPro-apoptotic proteinsNeuroinflammationNeurodegenerative diseasesSpatial learningInactivation of BadPro-apoptotic activity