Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation
Jiang Y, Armstrong D, Albrecht U, Atkins C, Noebels J, Eichele G, Sweatt J, Beaudet A. Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation. Neuron 1998, 21: 799-811. PMID: 9808466, DOI: 10.1016/s0896-6273(00)80596-6.Peer-Reviewed Original ResearchConceptsLong-term potentiationMaternal deficiencyAngelman syndromeNormal baseline synaptic transmissionBaseline synaptic transmissionE6-AP ubiquitinMotor dysfunctionSynaptic transmissionPhenotype of miceMice causesPotential biochemical basisPostmitotic neuronsLearning deficitsMiceDegradation of p53E6 proteinPotentiationP53Cytoplasmic p53UBE3ACytoplasmic abundanceDeficitsDeficiencyPhenotypeBiochemical basis