2002
A Rheostat Model for a Rapid and Reversible Form of Imprinting-Dependent Evolution
Beaudet AL, Jiang YH. A Rheostat Model for a Rapid and Reversible Form of Imprinting-Dependent Evolution. American Journal Of Human Genetics 2002, 70: 1389-1397. PMID: 11992247, PMCID: PMC379123, DOI: 10.1086/340969.Peer-Reviewed Original ResearchConceptsGenomic imprintingRheostat modelGene expressionSelective advantageNon-Mendelian inheritanceDosage-sensitive lociMajority of variantsEpigenetic variantsEvolutionary advantageForm of evolutionSilent alleleImprintingPhenotypeIntegrated mechanismEnhanced adaptabilityExpressionDeleterious effectsEvolutionMammalsHypervariabilityWide continuumGenesMendelianLociMechanism
1998
Imprinting in Angelman and Prader-Willi syndromes
Jiang Y, Tsai T, Bressler J, Beaudet A. Imprinting in Angelman and Prader-Willi syndromes. Current Opinion In Genetics & Development 1998, 8: 334-342. PMID: 9691003, DOI: 10.1016/s0959-437x(98)80091-9.Peer-Reviewed Original ResearchConceptsE6-AP ubiquitin-protein ligaseUbiquitin-protein ligaseAnalysis of methylationTissue-specific imprintingAngelman syndromeSNRPN promoterPrader-Willi syndromeAS genesMaternal chromosomesGene expressionGenomic sequencingPoint mutationsGenesBisulfite methodMethylationCandidate regionsImprintingHippocampal neuronsDrosophilaNecdinSNRPNLigaseChromosomesPromoterPurkinje cells