Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficient mice
Chung L, Wang X, Zhu L, Towers AJ, Cao X, Kim IH, Jiang YH. Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficient mice. Brain Research 2015, 1629: 340-350. PMID: 26474913, PMCID: PMC4744651, DOI: 10.1016/j.brainres.2015.10.015.Peer-Reviewed Original ResearchConceptsPrader-Willi syndromeClinical presentationClass ISynaptic transmissionExpression of CYFIP1Impaired synaptic transmissionRole of CYFIP1Breakpoint 2Severe clinical presentationLong-term depressionCued fear conditioningPaired-pulse facilitationZero-maze testHuman neuropsychiatric disordersClass II deletionsBreakpoints 1Neurological presentationAS patientsHippocampal CA1Deficient miceTerm depressionMaternal deficiencyPatientsHaploinsufficiency of Cyfip1Synaptic function