Differential Metabolites in Chinese Autistic Children: A Multi-Center Study Based on Urinary 1H-NMR Metabolomics Analysis
Ma Y, Zhou H, Li C, Zou X, Luo X, Wu L, Li T, Chen X, Mao M, Huang Y, Li E, An Y, Zhang L, Wang T, Xu X, Yan W, Jiang Y, Wang Y. Differential Metabolites in Chinese Autistic Children: A Multi-Center Study Based on Urinary 1H-NMR Metabolomics Analysis. Frontiers In Psychiatry 2021, 12: 624767. PMID: 34045978, PMCID: PMC8144639, DOI: 10.3389/fpsyt.2021.624767.Peer-Reviewed Original ResearchDifferential metabolitesHealthy childrenPathogenic mechanismsControl groupGuanidinoacetic acidAutism spectrum disorderROC curveMulti-center studyCharacteristic curve analysisH NMR metabolomics analysisSignificant diagnostic valueAmino acid metabolitesMetabolomic analysisN-methylnicotinamideEarly-onset neurodevelopmental disorderUnivariate analysisEarly diagnosisValuable biomarkerAcid metabolitesAmino acid metabolic pathwaysDiagnostic valueAutistic childrenCreatinineCurve analysisMetabolic variations