2022
Bayesian network mediation analysis with application to the brain functional connectome
Zhao Y, Chen T, Cai J, Lichenstein S, Potenza M, Yip S. Bayesian network mediation analysis with application to the brain functional connectome. Statistics In Medicine 2022, 41: 3991-4005. PMID: 35795965, PMCID: PMC10131252, DOI: 10.1002/sim.9488.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBrainConnectomeHumansMagnetic Resonance ImagingMediation AnalysisNerve NetConceptsStochastic block modelBayesian paradigmBrain functional connectomeBlock modelConnectivity weightsFunctional connectomeNetwork measurementsEffect componentApproach applicationBlock allocationOpioid abstinenceAnalytic approachNetwork neurosciencePractical illustrationTherapeutic interventionsMediation analysisNeural circuitsNetwork structureBrain functioningMediatorsFunctional networksFeature selectionApplicationsModelNetwork
2018
Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease
Freeze B, Acosta D, Pandya S, Zhao Y, Raj A. Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease. NeuroImage Clinical 2018, 18: 456-466. PMID: 29868450, PMCID: PMC5984599, DOI: 10.1016/j.nicl.2018.01.009.Peer-Reviewed Original ResearchConceptsRegional brain atrophyProgression Markers InitiativeBrain atrophyRegional atrophyParkinson's Progression Markers InitiativeMultivariable regression analysisSignificant predictorsHigh-resolution magnetic resonanceParkinson's disease pathogenesisAutosomal recessive PDPD-related genesRegional expressionResolution magnetic resonanceBrain atlasParkinson's diseaseRegional dysfunctionDisease pathogenesisAtrophyGenetic predictorsTop candidate genesExpression patternsAllen Brain AtlasRegression analysisPredictorsMagnetic resonanceRegional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes
Acosta D, Powell F, Zhao Y, Raj A. Regional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes. Alzheimer's & Dementia 2018, 14: 797-810. PMID: 29306583, PMCID: PMC5994366, DOI: 10.1016/j.jalz.2017.11.014.Peer-Reviewed Original Research