2024
Bayesian pathway analysis over brain network mediators for survival data
Tian X, Li F, Shen L, Esserman D, Zhao Y. Bayesian pathway analysis over brain network mediators for survival data. Biometrics 2024, 80: ujae132. PMID: 39530270, PMCID: PMC11555425, DOI: 10.1093/biomtc/ujae132.Peer-Reviewed Original ResearchConceptsAccelerated failure time modelFailure time modelBrain connectivityAlzheimer's Disease Neuroimaging Initiative studyMaximum information extractionResponse regressionBayesian approachInformation extractionTime modelSurvival dataNoisy componentsUnique edgeWhite matter fiber tractsNetwork configurationBrain networksInterconnection networksNetworkNetwork mediatorsBrain
2022
Bayesian network mediation analysis with application to the brain functional connectome
Zhao Y, Chen T, Cai J, Lichenstein S, Potenza M, Yip S. Bayesian network mediation analysis with application to the brain functional connectome. Statistics In Medicine 2022, 41: 3991-4005. PMID: 35795965, PMCID: PMC10131252, DOI: 10.1002/sim.9488.Peer-Reviewed Original ResearchConceptsStochastic block modelBayesian paradigmBrain functional connectomeBlock modelConnectivity weightsFunctional connectomeNetwork measurementsEffect componentApproach applicationBlock allocationOpioid abstinenceAnalytic approachNetwork neurosciencePractical illustrationTherapeutic interventionsMediation analysisNeural circuitsNetwork structureBrain functioningMediatorsFunctional networksFeature selectionApplicationsModelNetworkBayesian Interaction Selection Model for Multimodal Neuroimaging Data Analysis
Zhao Y, Wu B, Kang J. Bayesian Interaction Selection Model for Multimodal Neuroimaging Data Analysis. Biometrics 2022, 79: 655-668. PMID: 35220581, PMCID: PMC9418386, DOI: 10.1111/biom.13648.Peer-Reviewed Original ResearchIdentifying imaging genetic associations via regional morphometricity estimation.
Bao J, Wen Z, Kim M, Saykin AJ, Thompson PM, Zhao Y, Shen L. Identifying imaging genetic associations via regional morphometricity estimation. Biocomputing 2022, 27: 97-108. PMID: 34890140, PMCID: PMC8730533.Peer-Reviewed Original ResearchIdentifying highly heritable brain amyloid phenotypes through mining Alzheimer's imaging and sequencing biobank data.
Bao J, Wen Z, Kim M, Zhao X, Lee BN, Jung SH, Davatzikos C, Saykin AJ, Thompson PM, Kim D, Zhao Y, Shen L, . Identifying highly heritable brain amyloid phenotypes through mining Alzheimer's imaging and sequencing biobank data. Biocomputing 2022, 27: 109-120. PMID: 34890141, PMCID: PMC8730532.Peer-Reviewed Original Research
2018
Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease
Freeze B, Acosta D, Pandya S, Zhao Y, Raj A. Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease. NeuroImage Clinical 2018, 18: 456-466. PMID: 29868450, PMCID: PMC5984599, DOI: 10.1016/j.nicl.2018.01.009.Peer-Reviewed Original ResearchConceptsRegional brain atrophyProgression Markers InitiativeBrain atrophyRegional atrophyParkinson's Progression Markers InitiativeMultivariable regression analysisSignificant predictorsHigh-resolution magnetic resonanceParkinson's disease pathogenesisAutosomal recessive PDPD-related genesRegional expressionResolution magnetic resonanceBrain atlasParkinson's diseaseRegional dysfunctionDisease pathogenesisAtrophyGenetic predictorsTop candidate genesExpression patternsAllen Brain AtlasRegression analysisPredictorsMagnetic resonanceRegional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes
Acosta D, Powell F, Zhao Y, Raj A. Regional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes. Alzheimer's & Dementia 2018, 14: 797-810. PMID: 29306583, PMCID: PMC5994366, DOI: 10.1016/j.jalz.2017.11.014.Peer-Reviewed Original Research