2022
Sex-specific genetic association between psychiatric disorders and cognition, behavior and brain imaging in children and adults
Gui Y, Zhou X, Wang Z, Zhang Y, Wang Z, Zhou G, Zhao Y, Liu M, Lu H, Zhao H. Sex-specific genetic association between psychiatric disorders and cognition, behavior and brain imaging in children and adults. Translational Psychiatry 2022, 12: 347. PMID: 36028495, PMCID: PMC9418275, DOI: 10.1038/s41398-022-02041-6.Peer-Reviewed Original ResearchConceptsCognitive functionFluid intelligenceCognitive traitsAdolescent Brain Cognitive Development (ABCD) studyPsychiatric disordersCognitive Development StudyMediation effectMost psychiatric disordersPolygenic risk scoresBrain functionBrain structuresBrain imagingEarly etiologySex differencesDevelopment studiesPsychiatric traitsChildrenIntelligenceDisordersSchizophreniaGenetic riskAdultsTraitsCognitionAutism
2020
Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes
Ono JG, Kim BI, Zhao Y, Christos PJ, Tesfaigzi Y, Worgall TS, Worgall S. Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes. Journal Of Clinical Investigation 2020, 130: 921-926. PMID: 31929190, PMCID: PMC6994114, DOI: 10.1172/jci130860.Peer-Reviewed Original ResearchConceptsSphingolipid de novo synthesisNonallergic asthmaPeripheral blood cellsDe novo synthesisAirway hyperreactivityAllergic asthmaHuman asthmaAsthma pathogenesisChildhood asthmaAsthma riskAsthmaORMDL3 expressionAsthma susceptibilityBlood cellsNovo synthesisSphingolipid synthesisFuture therapeuticsDe novo sphingolipid synthesisChildrenORMDL3 overexpressionRiskDihydroceramideCeramideGenotypesHyperreactivity